Technology Process of 3-(1,3-dimethyl-2,4-dioxo-6-(2-(tritylthio)ethyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile
There total 6 articles about 3-(1,3-dimethyl-2,4-dioxo-6-(2-(tritylthio)ethyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
barium dihydroxide; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II);
In
acetic acid butyl ester; water;
at 80 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dichloromethane / 22 h / 20 °C / Inert atmosphere
2.1: potassium iodide; caesium carbonate / N,N-dimethyl acetamide / 41.7 h / 50 °C / Inert atmosphere
3.1: lithium diisopropyl amide / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
3.2: 2 h / -78 °C
4.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); barium dihydroxide / acetic acid butyl ester; water / 1.5 h / 80 °C
With
barium dihydroxide; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); caesium carbonate; potassium iodide; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; acetic acid butyl ester; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / 2-methyltetrahydrofuran / 0.67 h / 0 - 30 °C / Inert atmosphere
2.1: potassium iodide; caesium carbonate / N,N-dimethyl acetamide / 41.7 h / 50 °C / Inert atmosphere
3.1: lithium diisopropyl amide / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
3.2: 2 h / -78 °C
4.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); barium dihydroxide / acetic acid butyl ester; water / 1.5 h / 80 °C
With
barium dihydroxide; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium tert-butylate; caesium carbonate; potassium iodide; lithium diisopropyl amide;
In
tetrahydrofuran; 2-methyltetrahydrofuran; N,N-dimethyl acetamide; acetic acid butyl ester; water;
