6-(4-dimethylaminophenyl)pyrrolo[2,3-b]pyridine-1-carboxylic acid amide

Base Information

Chemical Name:6-(4-dimethylaminophenyl)pyrrolo[2,3-b]pyridine-1-carboxylic acid amide
CAS No.:1542067-01-5
Molecular Formula:C₁₆H₁₆N₄O
Molecular Weight:280.329
Hs Code.:

Synonyms:6-(4-dimethylaminophenyl)pyrrolo[2,3-b]pyridine-1-carboxylic acid amide

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Chemical Property of 6-(4-dimethylaminophenyl)pyrrolo[2,3-b]pyridine-1-carboxylic acid amide

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Technology Process of 6-(4-dimethylaminophenyl)pyrrolo[2,3-b]pyridine-1-carboxylic acid amide

There total 8 articles about 6-(4-dimethylaminophenyl)pyrrolo[2,3-b]pyridine-1-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1542067-01-5
6-(4-dimethylaminophenyl)pyrrolo[2,3-b]pyridine-1-carboxylic acid amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In toluene; at 80 ℃; for 2h;

With ammonia; In dichloromethane; toluene; at 20 ℃;

Reference yield:

: C₁₇H₁₄Cl₃N₃O₂

: 1542067-01-5
6-(4-dimethylaminophenyl)pyrrolo[2,3-b]pyridine-1-carboxylic acid amide

Guidance literature:: With ammonia; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2013.12.031

Reference yield:

: 271-63-6
7-Azaindole

: 1542067-01-5
6-(4-dimethylaminophenyl)pyrrolo[2,3-b]pyridine-1-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate; 3-chloro-benzenecarboperoxoic acid / water / 20 °C

2: 1,1,1,3,3,3-hexamethyl-disilazane / toluene / 1 h / 20 °C / Inert atmosphere

3: sodium hydroxide / methanol / 20 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate / 1,2-dimethoxyethane; water / 1.5 h / 110 - 115 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / toluene / 2 h / 20 °C

6: ammonia / dichloromethane / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonia; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; sodium hydroxide; In methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; 4: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2013.12.031