N'-hydroxy-5-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-1,3,4-thiadiazole-2-carboximidamide

Base Information

Chemical Name:N'-hydroxy-5-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-1,3,4-thiadiazole-2-carboximidamide
CAS No.:916889-36-6
Molecular Formula:C₁₅H₁₆F₃N₅O₂S
Molecular Weight:387.386
Hs Code.:

Synonyms:N'-hydroxy-5-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-1,3,4-thiadiazole-2-carboximidamide

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Chemical Property of N'-hydroxy-5-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-1,3,4-thiadiazole-2-carboximidamide

Chemical Property:

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Technology Process of N'-hydroxy-5-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-1,3,4-thiadiazole-2-carboximidamide

There total 3 articles about N'-hydroxy-5-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-1,3,4-thiadiazole-2-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 916889-35-5
5-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-1,3,4-thiadiazole-2-carbonitrile

: 916889-36-6
N'-hydroxy-5-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-1,3,4-thiadiazole-2-carboximidamide

Guidance literature:: With hydroxylamine hydrochloride; potassium carbonate; In ethanol; at 20 ℃;

Reference yield:

: 823782-74-7
4-[2-(trifluoromethyl)phenoxy]piperidine hydrochloride

: 916889-36-6
N'-hydroxy-5-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-1,3,4-thiadiazole-2-carboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / 80 °C

2: tert.-butylnitrite / acetonitrile / 2 h / 20 - 60 °C

3: hydroxylamine hydrochloride; potassium carbonate / ethanol / 20 °C

With tert.-butylnitrite; hydroxylamine hydrochloride; potassium carbonate; In ethanol; acetonitrile;

Reference yield:

: 916889-34-4
5-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-1,3,4-thiadiazol-2-amine

: 916889-36-6
N'-hydroxy-5-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-1,3,4-thiadiazole-2-carboximidamide

Guidance literature:: Multi-step reaction with 2 steps

1: tert.-butylnitrite / acetonitrile / 2 h / 20 - 60 °C

2: hydroxylamine hydrochloride; potassium carbonate / ethanol / 20 °C

With tert.-butylnitrite; hydroxylamine hydrochloride; potassium carbonate; In ethanol; acetonitrile;