4-[2-(Trifluoromethyl)phenoxy]piperidine hydrochloride

Base Information

• Chemical Name: 4-[2-(Trifluoromethyl)phenoxy]piperidine hydrochloride
• CAS No.: 823782-74-7
• Molecular Formula: C₁₂H₁₄F₃NO*ClH
• Molecular Weight: 281.705
• Hs Code.: 2933399090
• European Community (EC) Number: 969-623-1
• DSSTox Substance ID: DTXSID10589356
• Mol file: 823782-74-7.mol

Synonyms:823782-74-7;4-[2-(TRIFLUOROMETHYL)PHENOXY]PIPERIDINE HYDROCHLORIDE;4-(2-(trifluoromethyl)phenoxy)piperidine hydrochloride;4-(2-Trifluoromethyl-phenoxy)-piperidine hydrochloride;4-[2-(trifluoromethyl)phenoxy]piperidine;hydrochloride;4-[2-(trifluoromethyl)phenoxy]piperidine,hydrochloride;4-[2-(Trifluoromethyl)phenoxy]piperidine, HCl;4-(2-(trifluoromethyl)phenoxy)piperidinehydrochloride;4-[2-(Trifluoromethyl)phenoxy]piperidinehydrochloride;SCHEMBL473008;4-[2-(TRIFLUOROMETHYL)PHENOXY]PIPERIDINE HCL;DTXSID10589356;AR1796;MFCD03840133;AKOS005111303;SB43111;DS-11944;4-(2-Trifluoromethylphenoxy)piperidine HCl;DB-075838;CS-0156697;EN300-153095;A916201;4-(2-trifluoromethylphenoxy)piperidine hydrochloride;4-(2-Trifluoromethyl-phenoxy)piperidine hydrochloride;4-(2-(Trifluoromethyl)-phenoxy)piperidine hydrochloride;Z1723849108;4-[2-(Trifluoromethyl)phenoxy]piperidine hydrochloride, AldrichCPR;4-[2-(Trifluoromethyl)phenoxy]piperidine--hydrogen chloride (1/1)

Chemical Property of 4-[2-(Trifluoromethyl)phenoxy]piperidine hydrochloride

Chemical Property:

• PSA: 21.26000
• LogP: 3.96700
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 281.0794263
• Heavy Atom Count: 18
• Complexity: 238

Purity/Quality:

99%, ^*data from raw suppliers

4-[2-(Trifluoromethyl)phenoxy]piperidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CNCCC1OC2=CC=CC=C2C(F)(F)F.Cl

Technology Process of 4-[2-(Trifluoromethyl)phenoxy]piperidine hydrochloride

There total 5 articles about 4-[2-(Trifluoromethyl)phenoxy]piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

tert-butyl 4-[2-(trifluoromethyl)phenoxy]-piperidine-1-carboxylate (921605-76-7) → 4-[2-(trifluoromethyl)phenoxy]piperidine hydrochloride (823782-74-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

Reference yield: 70.0%

4-(2-(trifluoromethyl)phenoxy)piperidine (824390-04-7) → 4-[2-(trifluoromethyl)phenoxy]piperidine hydrochloride (823782-74-7)

Guidance literature:

With hydrogenchloride; In ethanol; isopropyl alcohol; at 20 ℃; for 3h;

Reference yield:

2-(trifluoromethyl)phenol (444-30-4) → 4-[2-(trifluoromethyl)phenoxy]piperidine hydrochloride (823782-74-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / N,N-dimethyl-formamide / 14 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm200319u

upstream raw materials:

2-(trifluoromethyl)phenol

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-[2-(trifluoromethyl)phenoxy]-piperidine-1-carboxylate

4-(2-(trifluoromethyl)phenoxy)piperidine

Downstream raw materials:

C₂₁H₂₂F₃N₃O₄

N'-hydroxy-5-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-1,3,4-thiadiazole-2-carboximidamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 823782-74-7 4-(2-TRIFLUOROMETHYL-PHENOXY)-PIPERIDINE HYDROCHLORIDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send