tert-butyl (1-(4-bromophenyl)-3-hydroxypropan-2-yl)carbamate

Base Information

• Chemical Name: tert-butyl (1-(4-bromophenyl)-3-hydroxypropan-2-yl)carbamate
• CAS No.: 1333114-52-5
• Molecular Formula: C₁₄H₂₀BrNO₃
• Molecular Weight: 330.222
• Mol file: 1333114-52-5.mol

Synonyms:tert-butyl (1-(4-bromophenyl)-3-hydroxypropan-2-yl)carbamate

Chemical Property of tert-butyl (1-(4-bromophenyl)-3-hydroxypropan-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (1-(4-bromophenyl)-3-hydroxypropan-2-yl)carbamate

There total 3 articles about tert-butyl (1-(4-bromophenyl)-3-hydroxypropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl (±)-3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate (132067-41-5) → tert-butyl (1-(4-bromophenyl)-3-hydroxypropan-2-yl)carbamate (1333114-52-5)

Guidance literature:

With sodium tetrahydroborate; lithium chloride hydrate; In tetrahydrofuran; ethanol; at 0 - 20 ℃;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 2-amino-3-(4-bromophenyl)propanol (86886-33-1) → tert-butyl (1-(4-bromophenyl)-3-hydroxypropan-2-yl)carbamate (1333114-52-5)

Guidance literature:

In methanol; at 50 ℃; for 1.5h; Cooling with ice;

Reference yield:

ethyl 2-amino-3-(4-bromophenyl) propanoate (166967-59-5) → tert-butyl (1-(4-bromophenyl)-3-hydroxypropan-2-yl)carbamate (1333114-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: sodium tetrahydroborate; lithium chloride hydrate / tetrahydrofuran; ethanol / 0 - 20 °C

With sodium tetrahydroborate; lithium chloride hydrate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;

upstream raw materials:

methyl (±)-3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate

ethyl 2-amino-3-(4-bromophenyl) propanoate

di-tert-butyl dicarbonate

2-amino-3-(4-bromophenyl)propanol

Downstream raw materials:

methyl 2-((3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propoxy)methyl)-benzoate

C₁₄H₁₈BrNO₃

4-(4-bromobenzyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

4-(4-bromobenzyl)-5-((2-methoxyphenyl)sulfonyl)-3,4,5,6-tetrahvdro-1H-benzo-[f][1,4]oxazocine