4-(4-bromobenzyl)-5-((2-methoxyphenyl)sulfonyl)-3,4,5,6-tetrahvdro-1H-benzo-[f][1,4]oxazocine

Base Information

• Chemical Name: 4-(4-bromobenzyl)-5-((2-methoxyphenyl)sulfonyl)-3,4,5,6-tetrahvdro-1H-benzo-[f][1,4]oxazocine
• CAS No.: 1333114-59-2
• Molecular Formula: C₂₄H₂₄BrNO₄S
• Molecular Weight: 502.429
• Mol file: 1333114-59-2.mol

Synonyms:4-(4-bromobenzyl)-5-((2-methoxyphenyl)sulfonyl)-3,4,5,6-tetrahvdro-1H-benzo-[f][1,4]oxazocine

Chemical Property of 4-(4-bromobenzyl)-5-((2-methoxyphenyl)sulfonyl)-3,4,5,6-tetrahvdro-1H-benzo-[f][1,4]oxazocine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-bromobenzyl)-5-((2-methoxyphenyl)sulfonyl)-3,4,5,6-tetrahvdro-1H-benzo-[f][1,4]oxazocine

There total 12 articles about 4-(4-bromobenzyl)-5-((2-methoxyphenyl)sulfonyl)-3,4,5,6-tetrahvdro-1H-benzo-[f][1,4]oxazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

4-(4-bromobenzyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine (1333114-58-1) + o-Methoxybenzenesulfonyl chloride (10130-87-7) → 4-(4-bromobenzyl)-5-((2-methoxyphenyl)sulfonyl)-3,4,5,6-tetrahvdro-1H-benzo-[f][1,4]oxazocine (1333114-59-2)

Guidance literature:

With triethylamine; dmap; In acetonitrile; at 20 ℃;

Reference yield:

p-bromo-DL-phenylalanine (14091-15-7) → 4-(4-bromobenzyl)-5-((2-methoxyphenyl)sulfonyl)-3,4,5,6-tetrahvdro-1H-benzo-[f][1,4]oxazocine (1333114-59-2)

Guidance literature:

Multi-step reaction with 9 steps

1.1: hydrogenchloride / Reflux

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: sodium tetrahydroborate; lithium chloride hydrate / tetrahydrofuran; ethanol / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

4.2: 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

6.1: N-Bromosuccinimide; triphenylphosphine / tetrahydrofuran / 2.33 h / 0 - 20 °C

7.1: dichloromethane / 2 h / 0 °C

8.1: potassium carbonate / tetrahydrofuran / 20 °C

9.1: dmap; triethylamine / acetonitrile / 20 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; N-Bromosuccinimide; lithium aluminium tetrahydride; lithium chloride hydrate; sodium hydride; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetonitrile; mineral oil;

Reference yield:

methyl 2-bromomethylbenzoate (2417-73-4) → 4-(4-bromobenzyl)-5-((2-methoxyphenyl)sulfonyl)-3,4,5,6-tetrahvdro-1H-benzo-[f][1,4]oxazocine (1333114-59-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

1.2: 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

3.1: N-Bromosuccinimide; triphenylphosphine / tetrahydrofuran / 2.33 h / 0 - 20 °C

4.1: dichloromethane / 2 h / 0 °C

5.1: potassium carbonate / tetrahydrofuran / 20 °C

6.1: dmap; triethylamine / acetonitrile / 20 °C

With dmap; N-Bromosuccinimide; lithium aluminium tetrahydride; sodium hydride; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; mineral oil;

upstream raw materials:

ortho-methylbenzoic acid

p-bromo-DL-phenylalanine

methyl 2-bromomethylbenzoate

methyl (±)-3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate