methyl [(6-chloro-3,4-dihydro-3-oxo-4-phenethylpyrazin-2-yl)amino]acetate

Base Information

• Chemical Name: methyl [(6-chloro-3,4-dihydro-3-oxo-4-phenethylpyrazin-2-yl)amino]acetate
• CAS No.: 947681-69-8
• Molecular Formula: C₁₅H₁₆ClN₃O₃
• Molecular Weight: 321.763
• Mol file: 947681-69-8.mol

Synonyms:methyl [(6-chloro-3,4-dihydro-3-oxo-4-phenethylpyrazin-2-yl)amino]acetate

Chemical Property of methyl [(6-chloro-3,4-dihydro-3-oxo-4-phenethylpyrazin-2-yl)amino]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl [(6-chloro-3,4-dihydro-3-oxo-4-phenethylpyrazin-2-yl)amino]acetate

There total 3 articles about methyl [(6-chloro-3,4-dihydro-3-oxo-4-phenethylpyrazin-2-yl)amino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + 3,5-dichloro-1-phenethyl-1H-pyrazin-2-one (138610-68-1) → methyl [(6-chloro-3,4-dihydro-3-oxo-4-phenethylpyrazin-2-yl)amino]acetate (947681-69-8)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1002/ejoc.200700180

Reference yield:

2-phenylethylaminoacetonitrile (3591-82-0) → methyl [(6-chloro-3,4-dihydro-3-oxo-4-phenethylpyrazin-2-yl)amino]acetate (947681-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 4.92 g / NEt₃*HCl / chlorobenzene / 24 h / 20 °C

2: 40 percent / NEt₃ / dimethylformamide / 80 °C

With triethylamine hydrochloride; triethylamine; In N,N-dimethyl-formamide; chlorobenzene;

DOI:10.1002/ejoc.200700180

Reference yield:

phenethylamine (64-04-0) → methyl [(6-chloro-3,4-dihydro-3-oxo-4-phenethylpyrazin-2-yl)amino]acetate (947681-69-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 4.92 g / NEt₃*HCl / chlorobenzene / 24 h / 20 °C

2: 40 percent / NEt₃ / dimethylformamide / 80 °C

With triethylamine hydrochloride; triethylamine; In N,N-dimethyl-formamide; chlorobenzene;

DOI:10.1002/ejoc.200700180

upstream raw materials:

glycine ethyl ester hydrochloride

3,5-dichloro-1-phenethyl-1H-pyrazin-2-one

2-phenylethylaminoacetonitrile

phenethylamine