138610-68-1Relevant articles and documents
Synthesis and fungicidal activity of 3,5-dichloropyrazin-2(1H)-one derivatives
Francois, Isabelle E.J.A.,Cammue, Bruno P.A.,Bresseleers, Sara,Fleuren, Hein,Hoornaert, Georges,Mehta, Vaibhav P.,Modha, Sachin G.,Van der Eycken, Erik V.,Thevissen, Karin
supporting information; experimental part, p. 4064 - 4066 (2010/03/25)
We synthesized a family of 3,5-dichloropyrazin-2(1H)-one derivatives and assessed their in vitro fungicidal activity against Candida albicans. Compounds 11 and 20 were most active against C. albicans and induced accumulation of reactive oxygen species in
Design, synthesis and evaluation of serine protease inhibitor analogues
Kamoune, Laila,De Borggraeve, Wim M.,Gielens, Constant,Voet, Arnout,Robeyns, Koen,De Maeyer, Marc,Van Meervelt, Luc,Compernolle, Frans,Hoornaert, Georges
, p. 2977 - 2986 (2008/02/10)
Recent efforts in the field of thrombin inhibitor research have focused on the identification of pyrazinone-containing compounds. In this manuscript we describe the synthesis of the new pyrazinones 12-36. All the targets were fully characterised and scree
