N-(tetrahydro-2H-pyran-4-ylmethyl)-3-({4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-8-quinolinamine

Base Information

Chemical Name:N-(tetrahydro-2H-pyran-4-ylmethyl)-3-({4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-8-quinolinamine
CAS No.:1066836-04-1
Molecular Formula:C₂₇H₃₃N₃O₄S
Molecular Weight:495.643
Hs Code.:

Synonyms:N-(tetrahydro-2H-pyran-4-ylmethyl)-3-({4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-8-quinolinamine

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Chemical Property of N-(tetrahydro-2H-pyran-4-ylmethyl)-3-({4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-8-quinolinamine

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Technology Process of N-(tetrahydro-2H-pyran-4-ylmethyl)-3-({4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-8-quinolinamine

There total 3 articles about N-(tetrahydro-2H-pyran-4-ylmethyl)-3-({4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-8-quinolinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 933792-11-1
3-[(4-chlorophenyl)sulfonyl]-8-fluoroquinoline

: 389621-78-7
(tetrahydro-2H-pyran-4-yl)methanamine hydrochloride

: 933792-04-2
3-[(4-chlorophenyl)sulfonyl]-N-(tetrahydro-2H-pyran-4-ylmethyl)-8-quinolinamine

: 1066836-04-1
N-(tetrahydro-2H-pyran-4-ylmethyl)-3-({4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-8-quinolinamine

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 150 ℃; for 4h;

Reference yield:

: 866782-59-4
8-fluoro-3-iodoquinoline

: 933792-04-2
3-[(4-chlorophenyl)sulfonyl]-N-(tetrahydro-2H-pyran-4-ylmethyl)-8-quinolinamine

: 1066836-04-1
N-(tetrahydro-2H-pyran-4-ylmethyl)-3-({4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-8-quinolinamine

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; potassium carbonate; N,N-dimethylethylenediamine / dimethyl sulfoxide / 8 h / 100 °C

2: potassium carbonate / dimethyl sulfoxide / 4 h / 150 °C

With copper(l) iodide; potassium carbonate; N,N-dimethylethylenediamine; In dimethyl sulfoxide;

Reference yield:

: 394-68-3
8-fluoroquinoline

: 933792-04-2
3-[(4-chlorophenyl)sulfonyl]-N-(tetrahydro-2H-pyran-4-ylmethyl)-8-quinolinamine

: 1066836-04-1
N-(tetrahydro-2H-pyran-4-ylmethyl)-3-({4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-8-quinolinamine

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide; sodium sulfite / water; acetic acid / 1.5 h / 60 - 80 °C

2: copper(l) iodide; potassium carbonate; N,N-dimethylethylenediamine / dimethyl sulfoxide / 8 h / 100 °C

3: potassium carbonate / dimethyl sulfoxide / 4 h / 150 °C

With N-iodo-succinimide; copper(l) iodide; potassium carbonate; N,N-dimethylethylenediamine; sodium sulfite; In water; acetic acid; dimethyl sulfoxide;