2-(4-Fluoro-phenyl)-1-(1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-piperidin-4-yl)-ethanone

Base Information

• Chemical Name: 2-(4-Fluoro-phenyl)-1-(1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-piperidin-4-yl)-ethanone
• CAS No.: 145021-98-3
• Molecular Formula: C₂₅H₂₉F₂NO₃
• Molecular Weight: 429.507

Synonyms:2-(4-Fluoro-phenyl)-1-(1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-piperidin-4-yl)-ethanone

Chemical Property of 2-(4-Fluoro-phenyl)-1-(1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-piperidin-4-yl)-ethanone

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 2-(4-Fluoro-phenyl)-1-(1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-piperidin-4-yl)-ethanone

There total 2 articles about 2-(4-Fluoro-phenyl)-1-(1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-piperidin-4-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(1-Benzyl-piperidin-4-yl)-2-(4-fluoro-phenyl)-ethanone; compound with (Z)-but-2-enedioic acid → 2-(4-Fluoro-phenyl)-1-(1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-piperidin-4-yl)-ethanone (145021-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium formate / 10percent Pd/C / methanol / 0.75 h / Heating

2: 195 mg / K₂CO₃, KI / acetonitrile / 24 h / Heating

With ammonium formate; potassium carbonate; potassium iodide; palladium on activated charcoal; In methanol; acetonitrile;

DOI:10.1021/jm00101a012

Reference yield:

2-(4-Fluoro-phenyl)-1-piperidin-4-yl-ethanone (78056-85-6) + 4-chloro-1-(4-fluorophenyl)-1,1-(ethylenedioxy)butane (3308-94-9) → 2-(4-Fluoro-phenyl)-1-(1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-piperidin-4-yl)-ethanone (145021-98-3)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; for 24h; Heating;

DOI:10.1021/jm00101a012

Reference yield: 6.0%

2-(4-Fluoro-phenyl)-1-(1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-piperidin-4-yl)-ethanone (145021-98-3) → 1-[4-(4-fluorophenyl)-4-oxobutyl]-4-[2-(4-fluorophenyl)-1-oxoethyl]piperidine

Guidance literature:

With hydrogenchloride; In ethanol; for 24h;

DOI:10.1021/jm00101a012

upstream raw materials:

2-(4-Fluoro-phenyl)-1-piperidin-4-yl-ethanone

4-chloro-1-(4-fluorophenyl)-1,1-(ethylenedioxy)butane

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