N-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

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Chemical Name:N-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide
CAS No.:1076690-54-4
Molecular Formula:C₂₀H₂₂BrN₃O₅S
Molecular Weight:496.382
Hs Code.:

Synonyms:N-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

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Chemical Property of N-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

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Technology Process of N-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

There total 5 articles about N-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1076690-88-4
N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-methanesulfonamide trifluoroacetate

: 4697-62-5
6-bromohomoveratric acid

: 1076690-54-4
N-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

Guidance literature:: 6-bromohomoveratric acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 1h;

N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-methanesulfonamide trifluoroacetate; With pyridine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; for 4h;

Reference yield:

: 1076690-82-8
3-(4-amino-phenyl)-4,5-dihydro-pyrazole-1-carboxylic acid tert-butyl ester

: 1076690-54-4
N-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1.25 h / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 20 °C

3.2: 4 h

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1076690-86-2
3-(4-methanesulfonylamino-phenyl)-4,5-dihydro-pyrazole-1-carboxylic acid tert-butyl ester

: 1076690-54-4
N-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1.25 h / 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 20 °C

2.2: 4 h

With oxalyl dichloride; trifluoroacetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;