Diethyl 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylmalonate

Base Information

Chemical Name:Diethyl 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylmalonate
CAS No.:170861-69-5
Molecular Formula:C₂₆H₂₉NO₆
Molecular Weight:451.519
Hs Code.:
DSSTox Substance ID:DTXSID501128119
Nikkaji Number:J964.591H
ChEMBL ID:CHEMBL57855

Synonyms:CHEMBL57855;SCHEMBL7897394;GNXHZXFHJQWEMB-UHFFFAOYSA-N;DTXSID501128119;Diethyl 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylmalonate;[4-[2-(2-Phenyl-5-methyloxazole-4-yl)ethoxy]benzyl]malonic acid diethyl ester;1,3-Diethyl 2-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]propanedioate;170861-69-5

Suppliers and Price of Diethyl 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylmalonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Diethyl 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylmalonate

Chemical Property:

XLogP3:5.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:13
Exact Mass:451.19948764
Heavy Atom Count:33
Complexity:582

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(CC1=CC=C(C=C1)OCCC2=C(OC(=N2)C3=CC=CC=C3)C)C(=O)OCC

Technology Process of Diethyl 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylmalonate

There total 3 articles about Diethyl 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 170861-70-8
diethyl 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidenemalonate

: 170861-69-5
diethyl 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylmalonate

Guidance literature:: palladium-carbon; In tetrahydrofuran; methanol;

Reference yield:

: 103788-59-6
4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzaldehyde

: 170861-69-5
diethyl 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylmalonate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidinium acetate / toluene / 4 h / Heating

2: H₂ / 5percent Pd/C / methanol; dioxane / Ambient temperature

With hydrogen; piperdinium acetate; palladium on activated charcoal; In 1,4-dioxane; methanol; toluene;
DOI:10.1021/jm970771m

Reference yield:

: 105-53-3
diethyl malonate

: 170861-69-5
diethyl 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylmalonate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidinium acetate / toluene / 4 h / Heating

2: H₂ / 5percent Pd/C / methanol; dioxane / Ambient temperature

With hydrogen; piperdinium acetate; palladium on activated charcoal; In 1,4-dioxane; methanol; toluene;
DOI:10.1021/jm970771m