4-<2-(4-methanesulfonyloxy butyl)-1,3-dioxalan-2-yl>-1-methylbutyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate

Base Information

• Chemical Name: 4-<2-(4-methanesulfonyloxy butyl)-1,3-dioxalan-2-yl>-1-methylbutyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate
• CAS No.: 111649-56-0
• Molecular Formula: C₂₉H₄₀O₉S₂
• Molecular Weight: 596.763
• Mol file: 111649-56-0.mol

Synonyms:4-<2-(4-methanesulfonyloxy butyl)-1,3-dioxalan-2-yl>-1-methylbutyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate

Chemical Property of 4-<2-(4-methanesulfonyloxy butyl)-1,3-dioxalan-2-yl>-1-methylbutyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<2-(4-methanesulfonyloxy butyl)-1,3-dioxalan-2-yl>-1-methylbutyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate

There total 21 articles about 4-<2-(4-methanesulfonyloxy butyl)-1,3-dioxalan-2-yl>-1-methylbutyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethylene glycol (107-21-1) + 9-methanesulfonyloxy-1-methyl-5-oxo-nonyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate (111649-54-8) → 4-<2-(4-methanesulfonyloxy butyl)-1,3-dioxalan-2-yl>-1-methylbutyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate (111649-56-0)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 6h; Heating;

DOI:10.1016/S0040-4020(01)90012-2

Reference yield:

tetrahydro-2H-2-pyranol (694-54-2) → 4-<2-(4-methanesulfonyloxy butyl)-1,3-dioxalan-2-yl>-1-methylbutyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate (111649-56-0)

Guidance literature:

Multi-step reaction with 12 steps

1: 79 percent / BF₃*OEt₂ / CHCl₃ / 7 h / Ambient temperature

2: 80 percent / toluene-p-sulfonic acid / CH₂Cl₂ / 6 h / Ambient temperature

3: 1.) n-BuLi / 1.) THF, -15 deg C; 2.) THF, -15 deg C to 0 deg C

4: 81 percent / toluene-p-sulfonic acid / methanol / 0.33 h / Ambient temperature

5: 89 percent / toluene-p-sulfonic acid / methanol

6: 82 percent / sodium borohydride / methanol / 8 h / Ambient temperature

7: 59 percent / pyridine / CH₂Cl₂ / Ambient temperature

8: toluene p-sulfonic acid / methanol

9: 87 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

10: 35 percent / mercuric chloride, mercuric oxide / acetonitrile; H₂O / 1 h / Heating

11: triethyl amine

12: 94 percent / toluene-p-sulfonic acid / benzene / 6 h / Heating

With pyridine; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; triethylamine; mercury dichloride; mercury(II) oxide; In methanol; dichloromethane; chloroform; water; acetonitrile; benzene;

DOI:10.1016/S0040-4020(01)90012-2

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → 4-<2-(4-methanesulfonyloxy butyl)-1,3-dioxalan-2-yl>-1-methylbutyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate (111649-56-0)

Guidance literature:

Multi-step reaction with 13 steps

1: aq. hydrochloric acid / Ambient temperature

2: 79 percent / BF₃*OEt₂ / CHCl₃ / 7 h / Ambient temperature

3: 80 percent / toluene-p-sulfonic acid / CH₂Cl₂ / 6 h / Ambient temperature

4: 1.) n-BuLi / 1.) THF, -15 deg C; 2.) THF, -15 deg C to 0 deg C

5: 81 percent / toluene-p-sulfonic acid / methanol / 0.33 h / Ambient temperature

6: 89 percent / toluene-p-sulfonic acid / methanol

7: 82 percent / sodium borohydride / methanol / 8 h / Ambient temperature

8: 59 percent / pyridine / CH₂Cl₂ / Ambient temperature

9: toluene p-sulfonic acid / methanol

10: 87 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

11: 35 percent / mercuric chloride, mercuric oxide / acetonitrile; H₂O / 1 h / Heating

12: triethyl amine

13: 94 percent / toluene-p-sulfonic acid / benzene / 6 h / Heating

With pyridine; hydrogenchloride; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; triethylamine; mercury dichloride; mercury(II) oxide; In methanol; dichloromethane; chloroform; water; acetonitrile; benzene;

DOI:10.1016/S0040-4020(01)90012-2

upstream raw materials:

ethylene glycol

9-methanesulfonyloxy-1-methyl-5-oxo-nonyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate

tetrahydro-2H-2-pyranol

3,4-dihydro-2H-pyran

Downstream raw materials:

4-<2-(4-iodobutyl)-1,3-dioxalan-2-yl>-1-methylbutyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate