N-<β-(1-oxo-1,2,3,4-tetrahydro-2-naphthyl)acetyl>-4-(p-fluorobenzoyl)piperidine bis(ethylene ketal)

Base Information

Chemical Name:N-<β-(1-oxo-1,2,3,4-tetrahydro-2-naphthyl)acetyl>-4-(p-fluorobenzoyl)piperidine bis(ethylene ketal)
CAS No.:157131-51-6
Molecular Formula:C₂₈H₃₂FNO₅
Molecular Weight:481.564
Hs Code.:

Synonyms:N-<β-(1-oxo-1,2,3,4-tetrahydro-2-naphthyl)acetyl>-4-(p-fluorobenzoyl)piperidine bis(ethylene ketal)

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Chemical Property of N-<β-(1-oxo-1,2,3,4-tetrahydro-2-naphthyl)acetyl>-4-(p-fluorobenzoyl)piperidine bis(ethylene ketal)

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Technology Process of N-<β-(1-oxo-1,2,3,4-tetrahydro-2-naphthyl)acetyl>-4-(p-fluorobenzoyl)piperidine bis(ethylene ketal)

There total 6 articles about N-<β-(1-oxo-1,2,3,4-tetrahydro-2-naphthyl)acetyl>-4-(p-fluorobenzoyl)piperidine bis(ethylene ketal) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 107-21-1
ethylene glycol

: 157131-44-7
N-<(1-oxo-1,2,3,4-tetrahydro-2-naphthyl)acetyl>-4-(p-fluorobenzoyl)piperidine

: 157131-51-6
N-<β-(1-oxo-1,2,3,4-tetrahydro-2-naphthyl)acetyl>-4-(p-fluorobenzoyl)piperidine bis(ethylene ketal)

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 22.5h; Heating;

Reference yield:

: 56346-57-7
(4-fluorophenyl)-piperidin-4-ylmethanone

: 157131-51-6
N-<β-(1-oxo-1,2,3,4-tetrahydro-2-naphthyl)acetyl>-4-(p-fluorobenzoyl)piperidine bis(ethylene ketal)

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / N-hydroxybenzotriazole, N,N-dicyclohexylcarbodiimide / 17 h / 0 - 20 °C

2: 95 percent / p-TsOH / toluene / 22.5 h / Heating

With benzotriazol-1-ol; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In toluene;

Reference yield:

: 41059-51-2
1-oxo-1,2,3,4-tetrahydro-2-naphthaleneacetic acid ethyl ester

: 157131-51-6
N-<β-(1-oxo-1,2,3,4-tetrahydro-2-naphthyl)acetyl>-4-(p-fluorobenzoyl)piperidine bis(ethylene ketal)

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / conc. aq. HCl

2: 81 percent / N-hydroxybenzotriazole, N,N-dicyclohexylcarbodiimide / 17 h / 0 - 20 °C

3: 95 percent / p-TsOH / toluene / 22.5 h / Heating

With hydrogenchloride; benzotriazol-1-ol; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In toluene;