rel-(2R,3R)-2-Hydroxy-3-chloro-2-(3-phenyl-1(S)-hydroxypropyl)cyclohexan-1-one

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Chemical Name:rel-(2R,3R)-2-Hydroxy-3-chloro-2-(3-phenyl-1(S)-hydroxypropyl)cyclohexan-1-one
CAS No.:132524-45-9
Molecular Formula:C₁₅H₁₉ClO₃
Molecular Weight:282.767
Hs Code.:

Synonyms:rel-(2R,3R)-2-Hydroxy-3-chloro-2-(3-phenyl-1(S)-hydroxypropyl)cyclohexan-1-one

Suppliers and Price of rel-(2R,3R)-2-Hydroxy-3-chloro-2-(3-phenyl-1(S)-hydroxypropyl)cyclohexan-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rel-(2R,3R)-2-Hydroxy-3-chloro-2-(3-phenyl-1(S)-hydroxypropyl)cyclohexan-1-one

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Technology Process of rel-(2R,3R)-2-Hydroxy-3-chloro-2-(3-phenyl-1(S)-hydroxypropyl)cyclohexan-1-one

There total 4 articles about rel-(2R,3R)-2-Hydroxy-3-chloro-2-(3-phenyl-1(S)-hydroxypropyl)cyclohexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 132524-42-6,132617-95-9,136233-48-2
syn-2,3-Oxirano-2-(3-phenyl-1-hydroxypropyl)cyclohexan-1-one

: 132524-45-9
rel-(2R,3R)-2-Hydroxy-3-chloro-2-(3-phenyl-1(S)-hydroxypropyl)cyclohexan-1-one

: 132524-44-8
(4aβ,5β,11bβ)-5H-4-Oxo-1,2,3,4,4a,6,7,11bβ-octahydro-4a,5-dihydroxydibenzocycloheptene

Guidance literature:: With tin(IV) chloride; at 20 ℃; for 24h;
DOI:10.1039/c39900001516

Reference yield:

: 930-68-7
cyclohexenone

: 132524-45-9
rel-(2R,3R)-2-Hydroxy-3-chloro-2-(3-phenyl-1(S)-hydroxypropyl)cyclohexan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / diethylaluminium iodide / CH₂Cl₂; toluene / 0.5 h / -15 °C

2: 61 percent / H₂O₂ (35percent), NaOH / methanol; H₂O / 0.5 h / 0 °C

3: 46 percent / SnCl₄ / CH₂Cl₂ / 24 h / 20 °C

With sodium hydroxide; dihydrogen peroxide; diethylaluminum iodide; tin(IV) chloride; In methanol; dichloromethane; water; toluene;
DOI:10.1016/S0040-4020(01)80982-0

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 132524-45-9
rel-(2R,3R)-2-Hydroxy-3-chloro-2-(3-phenyl-1(S)-hydroxypropyl)cyclohexan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / diethylaluminium iodide / CH₂Cl₂; toluene / 0.5 h / -15 °C

2: 61 percent / H₂O₂ (35percent), NaOH / methanol; H₂O / 0.5 h / 0 °C

3: 46 percent / SnCl₄ / CH₂Cl₂ / 24 h / 20 °C

With sodium hydroxide; dihydrogen peroxide; diethylaluminum iodide; tin(IV) chloride; In methanol; dichloromethane; water; toluene;
DOI:10.1016/S0040-4020(01)80982-0