(2Z,4R,5R)-5-hydroxy-2--4,5-diphenyl-2-pentenenitrile

Base Information

Chemical Name:(2Z,4R,5R)-5-hydroxy-2--4,5-diphenyl-2-pentenenitrile
CAS No.:147471-38-3
Molecular Formula:C₂₇H₂₈N₂O₂
Molecular Weight:412.532
Hs Code.:

(2Z,4R,5R)-5-hydroxy-2-<N-methy-N-(2-hydroxy-1-methyl-2-phenylethyl)amino>-4,5-diphenyl-2-pentenenitrile

Synonyms:(2Z,4R,5R)-5-hydroxy-2--4,5-diphenyl-2-pentenenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2Z,4R,5R)-5-hydroxy-2--4,5-diphenyl-2-pentenenitrile

Chemical Property:

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Technology Process of (2Z,4R,5R)-5-hydroxy-2--4,5-diphenyl-2-pentenenitrile

There total 1 articles about (2Z,4R,5R)-5-hydroxy-2--4,5-diphenyl-2-pentenenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-52-7
benzaldehyde

: 2--4-phenyl-3-butenenitrile

: (2Z,4S,5R)-5-hydroxy-2--4,5-diphenyl-2-pentenenitrile

: 147599-21-1
(2Z,4R,5S)-5-hydroxy-2--4,5-diphenyl-2-pentenenitrile

: 147471-38-3
(2Z,4R,5R)-5-hydroxy-2--4,5-diphenyl-2-pentenenitrile

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, -78 deg C, 2) THF, -78 deg C, 1 h;
DOI:10.1021/jo00059a027

Reference yield:

: 147471-38-3
(2Z,4R,5R)-5-hydroxy-2--4,5-diphenyl-2-pentenenitrile

: 147599-28-8
4-((2R,3R)-5-oxo-3-phenyltetrahydrofuran-2-yl)benzonitrile

Guidance literature:: With oxalic acid; In tetrahydrofuran; at 100 ℃; for 12h;
DOI:10.1021/jo00059a027

Reference yield:

: 147471-38-3
(2Z,4R,5R)-5-hydroxy-2--4,5-diphenyl-2-pentenenitrile

: (S)-1,2-diphenylbutane

Guidance literature:: Multi-step reaction with 4 steps

1: aq. oxalic acid / tetrahydrofuran / 12 h / 100 °C

2: 1) BH₃*SMe₂, 2) glycerin, H₂O / 1) THF, 100 deg C, 2) THF, reflux

3: Et₃N / CH₂Cl₂

4: LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; dimethylsulfide borane complex; water; oxalic acid; triethylamine; glycerol; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00059a027