(2R,4S,5R)-1-(4-tert-butyl-3-ethenylbenzoyl)-4-(hydroxymethyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid, 2-tert-butyl ester

Base Information

Chemical Name:(2R,4S,5R)-1-(4-tert-butyl-3-ethenylbenzoyl)-4-(hydroxymethyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid, 2-tert-butyl ester
CAS No.:933450-60-3
Molecular Formula:C₃₀H₃₈N₄O₄S
Molecular Weight:550.722
Hs Code.:

(2R,4S,5R)-1-(4-tert-butyl-3-ethenylbenzoyl)-4-(hydroxymethyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid, 2-tert-butyl ester

Synonyms:(2R,4S,5R)-1-(4-tert-butyl-3-ethenylbenzoyl)-4-(hydroxymethyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid, 2-tert-butyl ester

Suppliers and Price of (2R,4S,5R)-1-(4-tert-butyl-3-ethenylbenzoyl)-4-(hydroxymethyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid, 2-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4S,5R)-1-(4-tert-butyl-3-ethenylbenzoyl)-4-(hydroxymethyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid, 2-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4S,5R)-1-(4-tert-butyl-3-ethenylbenzoyl)-4-(hydroxymethyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid, 2-tert-butyl ester

There total 1 articles about (2R,4S,5R)-1-(4-tert-butyl-3-ethenylbenzoyl)-4-(hydroxymethyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid, 2-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 933450-59-0
(2R,4S,5R)-1-(4-tert-butyl-3-ethenylbenzoyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid, 2-tert-butyl ester, 4-methyl ester

: 933450-60-3
(2R,4S,5R)-1-(4-tert-butyl-3-ethenylbenzoyl)-4-(hydroxymethyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid, 2-tert-butyl ester

Guidance literature:: (2R,4S,5R)-1-(4-tert-butyl-3-ethenylbenzoyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid, 2-tert-butyl ester, 4-methyl ester; With lithium triethylborohydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 933450-60-3
(2R,4S,5R)-1-(4-tert-butyl-3-ethenylbenzoyl)-4-(hydroxymethyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid, 2-tert-butyl ester

: 74-88-4
methyl iodide

: (2R,4S,5R)-1-(4-tert-butyl-3-ethenylbenzoyl)-4-(methoxymethyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid, 2-tert-butyl ester

Guidance literature:: (2R,4S,5R)-1-(4-tert-butyl-3-ethenylbenzoyl)-4-(hydroxymethyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid, 2-tert-butyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

methyl iodide; In N,N-dimethyl-formamide; at 0 ℃; for 5h;