4-(4-Chloro-6-methyl-2-pyrimidinyl)morpholine

Base Information

• Chemical Name: 4-(4-Chloro-6-methyl-2-pyrimidinyl)morpholine
• CAS No.: 118121-82-7
• Molecular Formula: C9H12ClN3O
• Molecular Weight: 213.66
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID80357524
• Wikidata: Q82137477
• Mol file: 118121-82-7.mol

Synonyms:4-(4-Chloro-6-methyl-2-pyrimidinyl)morpholine;118121-82-7;4-(4-chloro-6-methylpyrimidin-2-yl)morpholine;EC-000.1387;Morpholine, 4-(4-chloro-6-methyl-2-pyrimidinyl)-;SCHEMBL5480430;DTXSID80357524;MFCD00181495;STL355120;AKOS000284150;CS-0280658;EN300-1290848

Chemical Property of 4-(4-Chloro-6-methyl-2-pyrimidinyl)morpholine

Chemical Property:

• Vapor Pressure: 6.24E-06mmHg at 25°C
• Refractive Index: 1.557
• Boiling Point: 378.5°Cat760mmHg
• Flash Point: 182.7°C
• PSA: 38.25000
• Density: 1.276g/cm³
• LogP: 1.34000
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 213.0668897
• Heavy Atom Count: 14
• Complexity: 187

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Chloro-6-methyl-2-pyrimidinyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=N1)N2CCOCC2)Cl
• Uses: 4-(4-Chloro-6-methyl-2-pyrimidinyl)morpholine can be used as amyloid beta modulators.

Technology Process of 4-(4-Chloro-6-methyl-2-pyrimidinyl)morpholine

There total 1 articles about 4-(4-Chloro-6-methyl-2-pyrimidinyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

morpholine (110-91-8,99108-56-2) + 2,4-dichloro-6-methylpyrimidine (5424-21-5) → 4-(2-chloro-6-methylpyrimidin-4-yl)morpholine (52026-43-4) + 4-(4-chloro-6-methyl-pyrimidin-2-yl)-morpholine (118121-82-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield: 31.0%

4-(4-chloro-6-methyl-pyrimidin-2-yl)-morpholine (118121-82-7) + 2-chloro-5-methoxyaniline (2401-24-3) → 4-(2-Chloro-5-methoxyanilino)-2-morpholino-6-(methyl)pyrimidine (438248-67-0)

Guidance literature:

upstream raw materials:

morpholine

2,4-dichloro-6-methylpyrimidine

Downstream raw materials:

4-(2-Chloro-5-methoxyanilino)-2-morpholino-6-(methyl)pyrimidine