(1S,3R,4R,7S)-1,7-bis(benzyloxymethyl)-7-(benzyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Base Information

Chemical Name:(1S,3R,4R,7S)-1,7-bis(benzyloxymethyl)-7-(benzyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane
CAS No.:1062270-57-8
Molecular Formula:C₃₃H₃₄N₂O₇
Molecular Weight:570.642
Hs Code.:

Synonyms:(1S,3R,4R,7S)-1,7-bis(benzyloxymethyl)-7-(benzyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

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Chemical Property of (1S,3R,4R,7S)-1,7-bis(benzyloxymethyl)-7-(benzyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

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Technology Process of (1S,3R,4R,7S)-1,7-bis(benzyloxymethyl)-7-(benzyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

There total 2 articles about (1S,3R,4R,7S)-1,7-bis(benzyloxymethyl)-7-(benzyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1062270-56-7
1-[3,5-di-O-benzyl-3-C-(benzyloxymethyl)-4-C-(hydroxymethyl)-β-D-ribofuranosyl]thymine

: 124-63-0
methanesulfonyl chloride

: 1062270-57-8
(1S,3R,4R,7S)-1,7-bis(benzyloxymethyl)-7-(benzyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: 1-[3,5-di-O-benzyl-3-C-(benzyloxymethyl)-4-C-(hydroxymethyl)-β-D-ribofuranosyl]thymine; methanesulfonyl chloride; With pyridine; In dichloromethane; at -40 - 0 ℃; for 7h; Inert atmosphere;

With sodium hydride; In 1,4-dioxane; oil; at 10 - 50 ℃;
DOI:10.1002/ejoc.200800716

Reference yield:

: 1062270-53-4
1-[2-O-acetyl-4-C-(benzoyloxymethyl)-3,5-di-O-benzyl-3-C-(benzyloxymethyl)-β-D-ribofuranosyl]thymine

: 1062270-57-8
(1S,3R,4R,7S)-1,7-bis(benzyloxymethyl)-7-(benzyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: 1-[2-O-acetyl-4-C-(benzoyloxymethyl)-3,5-di-O-benzyl-3-C-(benzyloxymethyl)-β-D-ribofuranosyl]thymine; With sodium methylate; In methanol;

With pyridine; methanesulfonyl chloride; In dichloromethane;

With sodium hydride; In 1,4-dioxane; Further stages.;
DOI:10.1080/15257770701542975