4,6-Dihydroxy-2-methoxy-3-methylbenzaldehyde

Base Information

Chemical Name:4,6-Dihydroxy-2-methoxy-3-methylbenzaldehyde
CAS No.:118093-05-3
Molecular Formula:C₉H₁₀O₄
Molecular Weight:182.176
Hs Code.:
DSSTox Substance ID:DTXSID50699049
Wikidata:Q82629730
Mol file:118093-05-3.mol

Synonyms:4,6-dihydroxy-2-methoxy-3-methylbenzaldehyde;118093-05-3;4,6-DIHYDROXY-2-METHOXY-3-METHYL BENZALDEHYDE;DTXSID50699049

Suppliers and Price of 4,6-Dihydroxy-2-methoxy-3-methylbenzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 4,6-Dihydroxy-2-methoxy-3-methylbenzaldehyde

Chemical Property:

PSA：66.76000
LogP:1.22730
XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:182.05790880
Heavy Atom Count:13
Complexity:183

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=C(C=C1O)O)C=O)OC

Technology Process of 4,6-Dihydroxy-2-methoxy-3-methylbenzaldehyde

There total 11 articles about 4,6-Dihydroxy-2-methoxy-3-methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 118093-03-1
3-formyl-2,6-dihydroxy-4-methoxy-5-methyl-benzoic acid methyl ester

: 118093-05-3
2-methoxy-3-methyl-4,6-dihydroxybenzaldehyde

Guidance literature:: With lithium hydroxide; In water; at 90 ℃; for 4h;
DOI:10.1002/anie.201705390

Reference yield:

: 2-methoxy-3-methyl-4,6-dibenzyloxybenzaldehyde

: 118093-05-3
2-methoxy-3-methyl-4,6-dihydroxybenzaldehyde

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; ethyl acetate; at 20 ℃; for 12h; under 760.051 - 3800.26 Torr;

Reference yield:

: 621-23-8
1,2,3-trimethoxybenzene

: 118093-05-3
2-methoxy-3-methyl-4,6-dihydroxybenzaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: trichlorophosphate / 1 h / 0 °C

2.1: hydrazine hydrate / ethylene glycol / 3 h / 80 °C

2.2: 3 h / 120 °C

3.1: trichlorophosphate / 0 °C

4.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

5.1: potassium carbonate / acetone / 60 °C / Cooling with ice

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 60 °C / Cooling with ice

7.1: palladium on activated charcoal; hydrogen / ethyl acetate; methanol / 12 h / 20 °C / 760.05 - 3800.26 Torr

With palladium on activated charcoal; hydrogen; boron tribromide; potassium carbonate; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In methanol; dichloromethane; ethylene glycol; ethyl acetate; N,N-dimethyl-formamide; acetone;