118093-03-1

Basic information

• Product Name: methyl 3-formyl-2,6-dihydroxy-4-methoxy-5-methylbenzoate
• Synonyms: methyl 3-formyl-2,6-dihydroxy-4-methoxy-5-methylbenzoate
• CAS NO: 118093-03-1
• Molecular Weight: 240.213
• Mol File: 118093-03-1.mol

Chemical Properties

• CAS DataBase Reference: methyl 3-formyl-2,6-dihydroxy-4-methoxy-5-methylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-formyl-2,6-dihydroxy-4-methoxy-5-methylbenzoate(118093-03-1)
• EPA Substance Registry System: methyl 3-formyl-2,6-dihydroxy-4-methoxy-5-methylbenzoate(118093-03-1)

Safety Data

• Hazardous Substances Data: 118093-03-1(Hazardous Substances Data)

Upstream product

• 98442-51-4 3-Formyl-2,6-dihydroxy-4-methoxy-benzoesaeuremethylester 
• 4885-02-3 Dichloromethyl methyl ether 
• 39828-28-9 2,6-Dihydroxy-4-methoxy-3-methyl-benzoesaeure-methylester 

Downstream Products

• 118093-04-2 2,6-dihydroxy-4-methoxy-3-methyl-5-(phenylimino-methyl)-benzoic acid methyl ester 
• 118093-05-3 2-methoxy-3-methyl-4,6-dihydroxybenzaldehyde 
• 125536-25-6 7-hydroxy-5-methoxy-6-methyl-2-phenyl-1-benzopyrylium perchlorate 
• 21722-30-5 methyl 4-methoxy-3,5-dimethylphloroglucinol carboxylate 

Relevant articles and documents

Enantioselective Total Synthesis of Berkeleyone A and Preaustinoids

Herein we report the first enantioselective total synthesis of 3,5-dimethylorsellinic acid-derived meroterpenoids (?)-berkeleyone A and its five congeners ((?)-preaustinoids A, A1, B, B1, and B2) in 12–15 steps, starting from commercially available 2,4,6-trihydroxybenzoic acid hydrate. Based upon the recognition of latent symmetry within D-ring, our convergent synthesis features two critical reactions: 1) a symmetry-breaking, diastereoselective dearomative alkylation to assemble the entire carbon core, and 2) a Sc(OTf)3-mediated sequential Krapcho dealkoxycarbonylation/carbonyl α-tert-alkylation to forge the intricate bicyclo[3.3.1]nonane framework. We also conducted our preliminary biomimetic investigations and uncovered a series of rearrangements (α-ketol, α-hydroxyl-β-diketone, etc.) responsible for the biomimetic diversification of (?)-berkeleyone A into its five preaustinoid congeners.

Biomimetic Synthesis of Complex Flavonoids Isolated from Daemonorops “Dragon's Blood”

The dragonbloodins are a pair of complex flavonoid trimers that have been isolated from the palm tree Daemonorops draco, one of the sources of the ancient resin known as “dragon's blood”. We present a short synthesis that clarifies their relative configur