methyl 8-ethyl-11,12-diphenyl-9H-benzo[f]imidazo[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine-3-carboxylate

Base Information

• Chemical Name: methyl 8-ethyl-11,12-diphenyl-9H-benzo[f]imidazo[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine-3-carboxylate
• CAS No.: 1450807-47-2
• Molecular Formula: C₂₈H₂₃N₅O₂
• Molecular Weight: 461.523

Synonyms:methyl 8-ethyl-11,12-diphenyl-9H-benzo[f]imidazo[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine-3-carboxylate

Chemical Property of methyl 8-ethyl-11,12-diphenyl-9H-benzo[f]imidazo[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine-3-carboxylate

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Technology Process of methyl 8-ethyl-11,12-diphenyl-9H-benzo[f]imidazo[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine-3-carboxylate

There total 3 articles about methyl 8-ethyl-11,12-diphenyl-9H-benzo[f]imidazo[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

pent-2-yn-1-amine (41282-41-1) + methyl 3-azido-4-formylbenzoate (1279718-17-0) + benzil (134-81-6) → methyl 8-ethyl-11,12-diphenyl-9H-benzo[f]imidazo[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine-3-carboxylate (1450807-47-2)

Guidance literature:

With indium(III) chloride; ammonium acetate; In methanol; at 80 ℃; for 20h; Sealed tube; Inert atmosphere;

DOI:10.1021/ol402045h

Reference yield:

1-bromo-pent-2-yne (16400-32-1) → methyl 8-ethyl-11,12-diphenyl-9H-benzo[f]imidazo[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine-3-carboxylate (1450807-47-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 24 h / 0 - 20 °C

2: triphenylphosphine; water / diethyl ether / 24 h / 20 °C

3: ammonium acetate; indium(III) chloride / methanol / 20 h / 80 °C / Sealed tube; Inert atmosphere

With indium(III) chloride; sodium azide; ammonium acetate; water; triphenylphosphine; In methanol; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/ol402045h

Reference yield:

methyl 4-formyl-3-nitrobenzoate (153813-69-5) → methyl 8-ethyl-11,12-diphenyl-9H-benzo[f]imidazo[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine-3-carboxylate (1450807-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N,N,N,N,N-hexamethylphosphoric triamide; sodium azide / 20 °C

2: ammonium acetate; indium(III) chloride / methanol / 20 h / 80 °C / Sealed tube; Inert atmosphere

With N,N,N,N,N,N-hexamethylphosphoric triamide; indium(III) chloride; sodium azide; ammonium acetate; In methanol;

DOI:10.1021/ol402045h

upstream raw materials:

1-bromo-pent-2-yne

pent-2-yn-1-amine

methyl 3-azido-4-formylbenzoate

benzil

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