2-Benzoxazolethiol

Base Information

• Chemical Name: 2-Benzoxazolethiol
• CAS No.: 118090-08-7
• Molecular Formula: C₇H₅NOS
• Molecular Weight: 151.189
• Mol file: 118090-08-7.mol

Synonyms:

Chemical Property of 2-Benzoxazolethiol

Chemical Property:

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzoxazolethiol

There total 19 articles about 2-Benzoxazolethiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.6%

benzoxazole (273-53-0,29791-96-6) → 2-sulfanyl-1,3-benzoxazole (2382-96-9,118090-08-7)

Guidance literature:

With 1.3-propanedithiol; potassium hydroxide; In dimethyl sulfoxide; at 130 ℃; for 12h; Inert atmosphere; Sealed tube;

Reference yield: 92.0%

Thiram (137-26-8,93196-73-7) + 2-amino-phenol (95-55-6) → 2-sulfanyl-1,3-benzoxazole (2382-96-9,118090-08-7)

Guidance literature:

In water; at 80 ℃; Green chemistry;

DOI:10.1039/c7gc02311a

Reference yield: 91.0%

potassium ethyl xanthogenate (140-89-6) + 2-amino-phenol (95-55-6) → 2-sulfanyl-1,3-benzoxazole (2382-96-9,118090-08-7)

Guidance literature:

potassium ethyl xanthogenate; 2-amino-phenol; In glycerol; at 155 ℃; for 0.116667h; Microwave irradiation;

With acetic acid; In ethanol; water; glycerol; pH=3 - 4;

DOI:10.1007/s00706-011-0551-1

upstream raw materials:

2-chloro-1,3-benzoxazole

bis(2-benzoxazolyl) disulfide

2-vinylthiobenzoxazole

carbon disulfide

Downstream raw materials:

benzoxazol-2'-yl-mercaptoacetic acid ethyl ester

2-(ethylthio)benzo[d]oxazol

N-(n-hexanoyl)aniline

4-nitrobenzyl benzoate

Refernces

• 1、 Svyatkina, L. I.,Abramova, N. D.,Dmitrieva, L. L.,Trzhtsinskaya, B. V.,Skvortsova, G. G.. "KINETICS OF THE ACIDIC HYDROLYSIS OF VINYL DERIVATIVES OF BENZIMIDAZOLE-2-THIONE AND BENZOXAZOL-2-ONE AND -2-THIONE". . p. 1190 - 1193. Retrieved 1982.
• 2、 El-Helby, Abdel-Ghany A.,Sakr, Helmy,Eissa, Ibrahim H.,Al-Karmalawy, Ahmed A.,El-Adl, Khaled. "Benzoxazole/benzothiazole-derived VEGFR-2 inhibitors: Design, synthesis, molecular docking, and anticancer evaluations". . . Retrieved 2019.
• 3、 Alterio, Vincenzo,Angeli, Andrea,Bozdag, Murat,Carta, Fabrizio,De Simone, Giuseppina,Esposito, Davide,Monti, Simona Maria,Supuran, Claudiu T.. "2-Mercaptobenzoxazoles: a class of carbonic anhydrase inhibitors with a novel binding mode to the enzyme active site". . p. 8297 - 8300. Retrieved 2020.
• 4、 Kayathi, Narendra Babu,Panga, Siva Sankar,Adivireddy, Padmaja,Venkatapuram, Padmavathi. "A green approach for the synthesis of benzazolyl pyrimidinyl carbamothioates under ultrasonication and their antimicrobial activity". . p. 2931 - 2943. Retrieved 2021.
• 5、 Liu, Xing,Liu, Min,Xu, Wan,Zeng, Meng-Tian,Zhu, Hui,Chang, Cai-Zhu,Dong, Zhi-Bing. "An environmentally benign and efficient synthesis of substituted benzothiazole-2-thiols, benzoxazole-2-thiols, and benzimidazoline-2-thiones in water". . p. 5591 - 5598. Retrieved 2017.
• 6、 Xiao, Yan,Jing, Bing,Liu, Xiaoxia,Xue, Hongyu,Liu, Yajun. "Metal-free C–H mercaptalization of benzothiazoles and benzoxazoles using 1,3-propanedithiol as thiol source". . p. 279 - 284. Retrieved 2019.
• 7、 Nesaragi, Aravind R.,Kamble, Ravindra R.,Bayannavar, Praveen K.,Metre, Tukaram V.,Kariduraganavar, Mahadevappa Y.,Margankop, Sheetal B.,Joshi, Shrinivas D.,Kumbar, Vijay M.. "Microwave facilitated one-pot three component synthesis of coumarin-benzoxazole clubbed 1,2,3-triazoles: Antimicrobial evaluation, molecular docking and in silico ADME studies". . p. 3460 - 3472. Retrieved 2021/10/02.