2-(3-bromo-4-methanesulfonylphenyl)-3-cyclopentylpropionic acid methyl ester

Base Information

Chemical Name:2-(3-bromo-4-methanesulfonylphenyl)-3-cyclopentylpropionic acid methyl ester
CAS No.:300355-69-5
Molecular Formula:C₁₆H₂₁BrO₄S
Molecular Weight:389.31
Hs Code.:

Synonyms:2-(3-bromo-4-methanesulfonylphenyl)-3-cyclopentylpropionic acid methyl ester

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Chemical Property of 2-(3-bromo-4-methanesulfonylphenyl)-3-cyclopentylpropionic acid methyl ester

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Technology Process of 2-(3-bromo-4-methanesulfonylphenyl)-3-cyclopentylpropionic acid methyl ester

There total 3 articles about 2-(3-bromo-4-methanesulfonylphenyl)-3-cyclopentylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2-(3-bromo-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid methyl ester

: 300355-69-5
2-(3-bromo-4-methanesulfonylphenyl)-3-cyclopentylpropionic acid methyl ester

Guidance literature:: With dihydrogen peroxide; In formic acid;

Reference yield:

: 16188-55-9
2-(4-(methylthio)phenyl)acetic acid

: 300355-69-5
2-(3-bromo-4-methanesulfonylphenyl)-3-cyclopentylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; methanol / 72 h / Inert atmosphere; Reflux

2.1: bromine / tetrachloromethane / 8 h / 25 °C / Inert atmosphere

3.1: n-butyllithium; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; diisopropylamine / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 15 h / -78 - 25 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 25 °C / Inert atmosphere

With methanol; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; sulfuric acid; bromine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane;
DOI:10.1021/jm3008689

Reference yield:

: 300355-67-3
(3-bromo-4-methylsulfanylphenyl)acetic acid methyl ester

: 300355-69-5
2-(3-bromo-4-methanesulfonylphenyl)-3-cyclopentylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; diisopropylamine / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 15 h / -78 - 25 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 25 °C / Inert atmosphere

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm3008689