[(3aS,4aS,6R,7R,8R,8aS,10aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-yl]-methanol

Base Information

Chemical Name:[(3aS,4aS,6R,7R,8R,8aS,10aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-yl]-methanol
CAS No.:725253-41-8
Molecular Formula:C₂₈H₃₆O₈
Molecular Weight:500.589
Hs Code.:

Synonyms:[(3aS,4aS,6R,7R,8R,8aS,10aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-yl]-methanol

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Chemical Property of [(3aS,4aS,6R,7R,8R,8aS,10aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-yl]-methanol

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Technology Process of [(3aS,4aS,6R,7R,8R,8aS,10aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-yl]-methanol

There total 6 articles about [(3aS,4aS,6R,7R,8R,8aS,10aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 725253-59-8
(3aS,4aS,5aR,8R,9aR,10R,10aS,12aR)-10-Benzyloxy-8-(4-methoxy-phenyl)-2,2-dimethyl-decahydro-1,3,5,7,9,11-hexaoxa-naphtho[2,3-f]azulene

: 725253-41-8
[(3aS,4aS,6R,7R,8R,8aS,10aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-yl]-methanol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 - 0 ℃;
DOI:10.1016/j.tetlet.2004.04.083

Reference yield:

: 252046-22-3
(2R,3R,4S,4aS,9aS)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)-2,3,4,4a,9,9a-hexahydro-6H-pyrano[3,2-b]oxepin

: 725253-41-8
[(3aS,4aS,6R,7R,8R,8aS,10aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-yl]-methanol

Guidance literature:: Multi-step reaction with 6 steps

1: AD-mix β; MeSO2NH2 / 2-methyl-propan-2-ol; H2O; various solvent(s) / 0 °C

2: CSA / CH₂Cl₂ / 20 °C

3: H₂ / Pd/C / ethyl acetate; methanol / 20 °C

4: CSA / CH₂Cl₂ / 20 °C

5: 92 percent / KOt-Bu; n-Bu₄NI / tetrahydrofuran / 20 °C

6: 100 percent / DIBAL-H / CH₂Cl₂ / -78 - 0 °C

With methanesulfonamide; camphor-10-sulfonic acid; potassium tert-butylate; hydrogen; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; 1,4-bis(9-O-dihydroquinidine)phthalazine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2004.04.083

Reference yield:

: 725253-39-4
(3aS,4aS,6R,7R,8R,8aS,10aR)-7,8-Bis-benzyloxy-6-benzyloxymethyl-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulene

: 725253-41-8
[(3aS,4aS,6R,7R,8R,8aS,10aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-yl]-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / ethyl acetate; methanol / 20 °C

2: CSA / CH₂Cl₂ / 20 °C

3: 92 percent / KOt-Bu; n-Bu₄NI / tetrahydrofuran / 20 °C

4: 100 percent / DIBAL-H / CH₂Cl₂ / -78 - 0 °C

With camphor-10-sulfonic acid; potassium tert-butylate; hydrogen; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.tetlet.2004.04.083