2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]-N-(4-methoxyphenyl)acetamide

Base Information

Chemical Name:2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]-N-(4-methoxyphenyl)acetamide
CAS No.:1253732-61-4
Molecular Formula:C₂₇H₂₇N₃O₆
Molecular Weight:489.528
Hs Code.:

Synonyms:2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]-N-(4-methoxyphenyl)acetamide

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Chemical Property of 2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]-N-(4-methoxyphenyl)acetamide

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Technology Process of 2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]-N-(4-methoxyphenyl)acetamide

There total 4 articles about 2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]-N-(4-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1044870-92-9
2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)acetic acid

: 104-94-9
4-methoxy-aniline

: 1253732-61-4
2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]-N-(4-methoxyphenyl)acetamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 60.1667h; Inert atmosphere;

Reference yield:

: 861856-50-0
(4-formyl-2,6-dimethyl-phenoxy)-acetic acid

: 1253732-61-4
2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]-N-(4-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 17.5 h / 120 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 60 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; sodium hydrogen sulfate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 2233-18-3
4-hydroxy-3,5-dimethylbenzaldehyde

: 1253732-61-4
2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]-N-(4-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / ethanol / 16 h / 95 °C / Inert atmosphere

2: sodium hydroxide; water / 0.5 h / 20 °C

3: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 17.5 h / 120 °C / Inert atmosphere

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 60 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; sodium hydrogen sulfate; water; potassium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In ethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;