2-methyl-2-(4-(3-methyl-2-oxo-8-phenyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile

Base Information

Chemical Name:2-methyl-2-(4-(3-methyl-2-oxo-8-phenyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile
CAS No.:1610680-70-0
Molecular Formula:C₂₇H₂₂N₄O
Molecular Weight:418.498
Hs Code.:

Synonyms:2-methyl-2-(4-(3-methyl-2-oxo-8-phenyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile

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Chemical Property of 2-methyl-2-(4-(3-methyl-2-oxo-8-phenyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile

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Technology Process of 2-methyl-2-(4-(3-methyl-2-oxo-8-phenyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile

There total 9 articles about 2-methyl-2-(4-(3-methyl-2-oxo-8-phenyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1610680-63-1
2-(4-(8-iodo-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

: 98-80-6
phenylboronic acid

: 1610680-70-0
2-methyl-2-(4-(3-methyl-2-oxo-8-phenyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; monoethylene glycol diethyl ether; water; at 175 ℃; for 0.25h; Inert atmosphere; Sealed tube; Microwave irradiation;
DOI:10.1021/jm500361r

Reference yield:

: 1203578-70-4,1345447-23-5
6-iodo-3-nitroquinolin-4-ol

: 1610680-70-0
2-methyl-2-(4-(3-methyl-2-oxo-8-phenyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate / 2 h / 20 - 120 °C

2: acetic acid / 3 h / 20 °C / Inert atmosphere

3: iron; ammonium chloride / ethanol; water / 2 h / Reflux; Heating

4: triethylamine / dichloromethane / 2 h / 0 - 20 °C

5: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 24 h / 20 °C / Sealed tube

6: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; monoethylene glycol diethyl ether / 0.25 h / 175 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; iron; potassium carbonate; ammonium chloride; acetic acid; triethylamine; sodium hydroxide; trichlorophosphate; In ethanol; dichloromethane; monoethylene glycol diethyl ether; water;
DOI:10.1021/jm500361r

Reference yield:

: 1628078-09-0
2-(4-((6-iodo-3-nitroquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile

: 1610680-70-0
2-methyl-2-(4-(3-methyl-2-oxo-8-phenyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: iron; ammonium chloride / ethanol; water / 2 h / Reflux; Heating

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 24 h / 20 °C / Sealed tube

4: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; monoethylene glycol diethyl ether / 0.25 h / 175 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; iron; potassium carbonate; ammonium chloride; triethylamine; sodium hydroxide; In ethanol; dichloromethane; monoethylene glycol diethyl ether; water;
DOI:10.1021/jm500361r