2-(4-methoxyphenyl)-5,5-bis(2,2,2-trifluoro-1,1-bis-trifluoromethylethoxymethyl)-[1,3]-dioxane

Base Information

Chemical Name:2-(4-methoxyphenyl)-5,5-bis(2,2,2-trifluoro-1,1-bis-trifluoromethylethoxymethyl)-[1,3]-dioxane
CAS No.:929552-50-1
Molecular Formula:C₂₁H₁₆F₁₈O₅
Molecular Weight:690.326
Hs Code.:

Synonyms:2-(4-methoxyphenyl)-5,5-bis(2,2,2-trifluoro-1,1-bis-trifluoromethylethoxymethyl)-[1,3]-dioxane

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Chemical Property of 2-(4-methoxyphenyl)-5,5-bis(2,2,2-trifluoro-1,1-bis-trifluoromethylethoxymethyl)-[1,3]-dioxane

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Technology Process of 2-(4-methoxyphenyl)-5,5-bis(2,2,2-trifluoro-1,1-bis-trifluoromethylethoxymethyl)-[1,3]-dioxane

There total 4 articles about 2-(4-methoxyphenyl)-5,5-bis(2,2,2-trifluoro-1,1-bis-trifluoromethylethoxymethyl)-[1,3]-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 2378-02-1
1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-ol

: 929552-50-1
2-(4-methoxyphenyl)-5,5-bis(2,2,2-trifluoro-1,1-bis-trifluoromethylethoxymethyl)-[1,3]-dioxane

Guidance literature:: 5,5-bis(hydroxymethyl)-2-(p-methoxyphenyl)-1,3-dioxane; With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 0.333333h; Molecular sieve;

1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-ol; In tetrahydrofuran; at 45 ℃; for 30h; Sealed vessel;

Reference yield: 98.0%

: 2378-02-1
1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-ol

: 122788-52-7
5,5-bis(hydroxymethyl)-2-(4-methoxyphenyl)-1,3-dioxane

: 929552-50-1
2-(4-methoxyphenyl)-5,5-bis(2,2,2-trifluoro-1,1-bis-trifluoromethylethoxymethyl)-[1,3]-dioxane

Guidance literature:: With 4 A molecular sieve; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 45 ℃; for 30h;
DOI:10.1021/jo0616308

Reference yield:

: 115-77-5
Pentaerythritol

: 929552-50-1
2-(4-methoxyphenyl)-5,5-bis(2,2,2-trifluoro-1,1-bis-trifluoromethylethoxymethyl)-[1,3]-dioxane

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / HCl / H₂O / 4 h / 20 °C

2: 98 percent / triphenylphosphine; diethylazodicarboxylate; molecular sieves 4 Angstroem / tetrahydrofuran / 30 h / 45 °C

With hydrogenchloride; 4 A molecular sieve; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; water;
DOI:10.1021/jo0616308