(E)-3-[(1R)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinol-1-yl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

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Chemical Name:(E)-3-[(1R)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinol-1-yl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene
CAS No.:341544-05-6
Molecular Formula:C₂₉H₄₅NO₄
Molecular Weight:471.681
Hs Code.:

Synonyms:(E)-3-[(1R)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinol-1-yl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

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Chemical Property of (E)-3-[(1R)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinol-1-yl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

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Technology Process of (E)-3-[(1R)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinol-1-yl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

There total 2 articles about (E)-3-[(1R)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinol-1-yl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4721-98-6
6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline

: 257861-22-6
acrolein (R,R)-1,2-dicyclohexylethylene acetal

: (Z)-3-[6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinol-1-yl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

: (E)-3-[(1S)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinol-1-yl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

: 341544-05-6
(E)-3-[(1R)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinol-1-yl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

Guidance literature:: acrolein (R,R)-1,2-dicyclohexylethylene acetal; With titanium(IV) isopropylate; isopropylmagnesium chloride; In diethyl ether; at -50 - -40 ℃; for 1.5h;

6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline; In diethyl ether; at -40 - 20 ℃; for 4h; Further stages. Title compound not separated from byproducts.;
DOI:10.1021/ja004140k

Reference yield:

: 120850-92-2
(1R,2R)-1,2-dicyclohexyl-1,2-ethanediol

: 341544-05-6
(E)-3-[(1R)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinol-1-yl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / p-toluenesulfonic acid hydrate / CH₂Cl₂ / 2 h / 20 °C

2.1: Ti(O-i-Pr)4; i-PrMgCl / diethyl ether / 1.5 h / -50 - -40 °C

2.2: diethyl ether / 4 h / -40 - 20 °C

With titanium(IV) isopropylate; isopropylmagnesium chloride; toluene-4-sulfonic acid; In diethyl ether; dichloromethane;
DOI:10.1021/ja004140k