(S)-2-benzyloxy-1-((4R,5R)-5-((S)-2-benzyloxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-N-tosylethanamine

Base Information

Chemical Name:(S)-2-benzyloxy-1-((4R,5R)-5-((S)-2-benzyloxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-N-tosylethanamine
CAS No.:914982-45-9
Molecular Formula:C₃₇H₄₄N₂O₈S₂
Molecular Weight:708.897
Hs Code.:

Synonyms:(S)-2-benzyloxy-1-((4R,5R)-5-((S)-2-benzyloxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-N-tosylethanamine

Suppliers and Price of (S)-2-benzyloxy-1-((4R,5R)-5-((S)-2-benzyloxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-N-tosylethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-benzyloxy-1-((4R,5R)-5-((S)-2-benzyloxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-N-tosylethanamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-benzyloxy-1-((4R,5R)-5-((S)-2-benzyloxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-N-tosylethanamine

There total 8 articles about (S)-2-benzyloxy-1-((4R,5R)-5-((S)-2-benzyloxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-N-tosylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 98-59-9
p-toluenesulfonyl chloride

: 142285-66-3
3,5-diamino-1,6-di-O-benzyl-2,5-dideoxy-3,4-O-methylethylidene-L-iditol

: 914982-45-9
(S)-2-benzyloxy-1-((4R,5R)-5-((S)-2-benzyloxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-N-tosylethanamine

Guidance literature:: With pyridine; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.tet.2006.08.035

Reference yield:

: 61490-28-6
1,3:4,6-di-O-benzylidene-D-mannitol

: 914982-45-9
(S)-2-benzyloxy-1-((4R,5R)-5-((S)-2-benzyloxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-N-tosylethanamine

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

2: 78 percent / BF₃*Et₂O; Et₃SiH / CH₂Cl₂ / 1 h

3: 80 percent / pTSA / acetone / 5 h / 20 °C

4: 91 percent / sodium azide / dimethylformamide / 24 h / 110 °C

5: 95 percent / hydrogen / Lindlar's catalyst / methanol / 4 h / 28 °C / 760 Torr

6: 86 percent / pyridine / 3 h / 0 - 20 °C

With pyridine; triethylsilane; sodium azide; boron trifluoride diethyl etherate; hydrogen; toluene-4-sulfonic acid; triethylamine; Lindlar's catalyst; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tet.2006.08.035

Reference yield:

: 69-65-8
mannitol

: 914982-45-9
(S)-2-benzyloxy-1-((4R,5R)-5-((S)-2-benzyloxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-N-tosylethanamine

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / H₂SO₄ / dimethylformamide / 120 h / 20 °C

2: 82 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

3: 78 percent / BF₃*Et₂O; Et₃SiH / CH₂Cl₂ / 1 h

4: 80 percent / pTSA / acetone / 5 h / 20 °C

5: 91 percent / sodium azide / dimethylformamide / 24 h / 110 °C

6: 95 percent / hydrogen / Lindlar's catalyst / methanol / 4 h / 28 °C / 760 Torr

7: 86 percent / pyridine / 3 h / 0 - 20 °C

With pyridine; triethylsilane; sodium azide; sulfuric acid; boron trifluoride diethyl etherate; hydrogen; toluene-4-sulfonic acid; triethylamine; Lindlar's catalyst; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tet.2006.08.035