1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroacetyl)amino]-piperidine-1-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroacetyl)amino]-piperidine-1-carboxylate
CAS No.:710979-07-0
Molecular Formula:C₂₀H₂₄F₆N₂O₃
Molecular Weight:454.413
Hs Code.:

Synonyms:1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroacetyl)amino]-piperidine-1-carboxylate

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Chemical Property of 1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroacetyl)amino]-piperidine-1-carboxylate

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Technology Process of 1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroacetyl)amino]-piperidine-1-carboxylate

There total 3 articles about 1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroacetyl)amino]-piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 710967-99-0
4-(2-trifluoromethylbenzylamino)piperidine-1-carboxylic acid tert-butyl ester

: 407-25-0
trifluoroacetic anhydride

: 710979-07-0
1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroacetyl)amino]-piperidine-1-carboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2006.02.008

Reference yield:

: 3048-01-9
o-trifluoromethylbenzylamine

: 710979-07-0
1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroacetyl)amino]-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol

2: 81 percent / DMAP; Et₃N / CH₂Cl₂

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.02.008

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 710979-07-0
1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroacetyl)amino]-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol

2: 81 percent / DMAP; Et₃N / CH₂Cl₂

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.02.008