1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroetyl)amino]-piperidine-1-carboxylate

Base Information

• Chemical Name: 1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroetyl)amino]-piperidine-1-carboxylate
• CAS No.: 710979-14-9
• Molecular Formula: C₂₀H₂₆F₆N₂O₂
• Molecular Weight: 440.429

Synonyms:1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroetyl)amino]-piperidine-1-carboxylate

Chemical Property of 1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroetyl)amino]-piperidine-1-carboxylate

Chemical Property:

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Technology Process of 1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroetyl)amino]-piperidine-1-carboxylate

There total 4 articles about 1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroetyl)amino]-piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroacetyl)amino]-piperidine-1-carboxylate (710979-07-0) → 1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroetyl)amino]-piperidine-1-carboxylate (710979-14-9)

Guidance literature:

With borane; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2006.02.008

Reference yield:

o-trifluoromethylbenzylamine (3048-01-9) → 1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroetyl)amino]-piperidine-1-carboxylate (710979-14-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethanol

2: 81 percent / DMAP; Et₃N / CH₂Cl₂

3: 70 percent / BH₃ / tetrahydrofuran

With dmap; borane; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.02.008

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroetyl)amino]-piperidine-1-carboxylate (710979-14-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethanol

2: 81 percent / DMAP; Et₃N / CH₂Cl₂

3: 70 percent / BH₃ / tetrahydrofuran

With dmap; borane; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.02.008

upstream raw materials:

1,1-dimethylethyl 4-[{[2-(trifluoromethyl)phenyl]methyl}(2,2,2-trifluoroacetyl)amino]-piperidine-1-carboxylate

4-(2-trifluoromethylbenzylamino)piperidine-1-carboxylic acid tert-butyl ester

o-trifluoromethylbenzylamine

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

piperidin-4-yl-(2,2,2-trifluoro-ethyl)-(2-trifluoromethyl-benzyl)-amine

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