{7-chloro-4-oxo-3-[3-(trifluoromethyl)phenyl]-4H-pyrido[1,2-a]pyrimidin-2-yl}methyl acetate

Base Information

Chemical Name:{7-chloro-4-oxo-3-[3-(trifluoromethyl)phenyl]-4H-pyrido[1,2-a]pyrimidin-2-yl}methyl acetate
CAS No.:1350908-03-0
Molecular Formula:C₁₈H₁₂ClF₃N₂O₃
Molecular Weight:396.753
Hs Code.:

Synonyms:{7-chloro-4-oxo-3-[3-(trifluoromethyl)phenyl]-4H-pyrido[1,2-a]pyrimidin-2-yl}methyl acetate

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Chemical Property of {7-chloro-4-oxo-3-[3-(trifluoromethyl)phenyl]-4H-pyrido[1,2-a]pyrimidin-2-yl}methyl acetate

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Technology Process of {7-chloro-4-oxo-3-[3-(trifluoromethyl)phenyl]-4H-pyrido[1,2-a]pyrimidin-2-yl}methyl acetate

There total 4 articles about {7-chloro-4-oxo-3-[3-(trifluoromethyl)phenyl]-4H-pyrido[1,2-a]pyrimidin-2-yl}methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1350907-95-7
(7-chloro-3-iodo-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl acetate

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1350908-03-0
{7-chloro-4-oxo-3-[3-(trifluoromethyl)phenyl]-4H-pyrido[1,2-a]pyrimidin-2-yl}methyl acetate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; ethanol; at 100 ℃; for 2h; Microwave irradiation;
DOI:10.1055/s-0030-1260197

Reference yield:

: 817206-07-8
7-chloro-2-(chloromethyl)-3-iodo-4H-pyrido[1,2-a]pyrimidin-4-one

: 1350908-03-0
{7-chloro-4-oxo-3-[3-(trifluoromethyl)phenyl]-4H-pyrido[1,2-a]pyrimidin-2-yl}methyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 5 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; ethanol / 2 h / 100 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1055/s-0030-1260197

Reference yield:

: 162469-87-6
2-chloromethyl-6-chloro-4H-pyrido<1,2-a>pyrimidin-4-one

: 1350908-03-0
{7-chloro-4-oxo-3-[3-(trifluoromethyl)phenyl]-4H-pyrido[1,2-a]pyrimidin-2-yl}methyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide / acetonitrile / 16 h / Reflux

2: N,N-dimethyl-formamide / 5 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; ethanol / 2 h / 100 °C / Microwave irradiation

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; acetonitrile; 3: Suzuki coupling;
DOI:10.1055/s-0030-1260197