3',5‘-O-bis(tert-butyldimethylsilyl)-5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

Base Information

Chemical Name:3',5‘-O-bis(tert-butyldimethylsilyl)-5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine
CAS No.:1372854-87-9
Molecular Formula:C₃₄H₅₈N₄O₈Si₂
Molecular Weight:707.028
Hs Code.:

Synonyms:3',5‘-O-bis(tert-butyldimethylsilyl)-5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3',5‘-O-bis(tert-butyldimethylsilyl)-5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

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Technology Process of 3',5‘-O-bis(tert-butyldimethylsilyl)-5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

There total 10 articles about 3',5‘-O-bis(tert-butyldimethylsilyl)-5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₉H₇₉N₃O₁₁SSi₂

: 1372854-87-9
3',5‘-O-bis(tert-butyldimethylsilyl)-5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

Guidance literature:: With ammonia; In 1,4-dioxane; at 90 ℃;
DOI:10.1002/anie.201106516

Reference yield:

: 1372854-34-6
(R/S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-1-propanol

: 1372854-87-9
3',5‘-O-bis(tert-butyldimethylsilyl)-5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

Guidance literature:: Multi-step reaction with 7 steps

1: dmap / dichloromethane / 20 °C / Inert atmosphere

2: potassium carbonate / methanol / 1 h / Reflux

3: 0.75 h / 110 °C / Inert atmosphere

4: ammonium fluoride / methanol / 12 h / 50 °C / Inert atmosphere

5: 1H-imidazole / N,N-dimethyl-formamide / 6 h / 20 °C

6: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

7: ammonia / 1,4-dioxane / 90 °C

With 1H-imidazole; dmap; ammonium fluoride; ammonia; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201106516

Reference yield:

: 1372854-86-8
3’,5’-O-bis(tert-butyldimethylsilyl)-5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2'-deoxyuridine

: 1372854-87-9
3',5‘-O-bis(tert-butyldimethylsilyl)-5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: ammonia / 1,4-dioxane / 90 °C

With dmap; ammonia; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1002/anie.201106516