5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

Base Information

Chemical Name:5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine
CAS No.:1372854-88-0
Molecular Formula:C₂₂H₃₀N₄O₈
Molecular Weight:478.502
Hs Code.:

Synonyms:5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

Suppliers and Price of 5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

There total 11 articles about 5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1372854-87-9
3',5‘-O-bis(tert-butyldimethylsilyl)-5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

: 1372854-88-0
5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1002/anie.201106516

Reference yield:

: C₄₉H₇₉N₃O₁₁SSi₂

: 1372854-88-0
5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / 1,4-dioxane / 90 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

With tetrabutyl ammonium fluoride; ammonia; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1002/anie.201106516

Reference yield:

: 1372854-34-6
(R/S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-1-propanol

: 1372854-88-0
5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

Guidance literature:: Multi-step reaction with 8 steps

1: dmap / dichloromethane / 20 °C / Inert atmosphere

2: potassium carbonate / methanol / 1 h / Reflux

3: 0.75 h / 110 °C / Inert atmosphere

4: ammonium fluoride / methanol / 12 h / 50 °C / Inert atmosphere

5: 1H-imidazole / N,N-dimethyl-formamide / 6 h / 20 °C

6: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

7: ammonia / 1,4-dioxane / 90 °C

8: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

With 1H-imidazole; dmap; ammonium fluoride; tetrabutyl ammonium fluoride; ammonia; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201106516