(S)-1-(2-(2-(3-(3,4-dimethylphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile oxalate

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Chemical Name:(S)-1-(2-(2-(3-(3,4-dimethylphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile oxalate
CAS No.:1145965-99-6
Molecular Formula:C₂H₂O₄*C₂₀H₂₇N₅O₄
Molecular Weight:491.501
Hs Code.:

Synonyms:(S)-1-(2-(2-(3-(3,4-dimethylphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile oxalate

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Chemical Property of (S)-1-(2-(2-(3-(3,4-dimethylphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile oxalate

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Technology Process of (S)-1-(2-(2-(3-(3,4-dimethylphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile oxalate

There total 9 articles about (S)-1-(2-(2-(3-(3,4-dimethylphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.5%

: 1145965-74-7
(S)-1-(2-(2-(3-(3,4-dimethylphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile

: 144-62-7,97993-78-7
oxalic acid

: 1145965-99-6
(S)-1-(2-(2-(3-(3,4-dimethylphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile oxalate

Guidance literature:: In methanol; at 0 - 5 ℃; for 2h;

Reference yield:

: 1170210-31-7
1-(2-bromoethyl)-3-(3,4-dimethoxyphenyl)imidazolidin-2-one

: 1145966-18-2
(S)-1-(2-aminoacetyl)-pyrrolidine-2-carbonitrile trifluoroacetic acid salt

: 144-62-7,97993-78-7
oxalic acid

: 1145965-99-6
(S)-1-(2-(2-(3-(3,4-dimethylphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile oxalate

Guidance literature:: (S)-1-(2-aminoacetyl)-pyrrolidine-2-carbonitrile trifluoroacetic acid salt; With potassium carbonate; In acetonitrile; for 0.5h;

1-(2-bromoethyl)-3-(3,4-dimethoxyphenyl)imidazolidin-2-one; In acetonitrile; at 20 ℃; for 48h;

oxalic acid; In isopropyl alcohol;
DOI:10.1016/j.ejmech.2009.03.021

Reference yield:

: 37527-66-5
3,4-dimethoxyphenylisocyanate

: 1145965-99-6
(S)-1-(2-(2-(3-(3,4-dimethylphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile oxalate

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 0 - 20 °C

2: phosphorus tribromide; sodium hydrogencarbonate / dichloromethane / 3 h / Heating

3: potassium carbonate / acetonitrile / 48.5 h / 20 °C

4: methanol / 2 h / 0 - 5 °C

With phosphorus tribromide; sodium hydrogencarbonate; potassium carbonate; In methanol; dichloromethane; acetonitrile;