2-benzyl-2-{[(1E/Z)-2,2-dimethylpropylidene]amino}-4-(methylthio)-1-phenylbutan-1-one

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Chemical Name:2-benzyl-2-{[(1E/Z)-2,2-dimethylpropylidene]amino}-4-(methylthio)-1-phenylbutan-1-one
CAS No.:649723-56-8
Molecular Formula:C₂₃H₂₉NOS
Molecular Weight:367.555
Hs Code.:

Synonyms:2-benzyl-2-{[(1E/Z)-2,2-dimethylpropylidene]amino}-4-(methylthio)-1-phenylbutan-1-one

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Chemical Property of 2-benzyl-2-{[(1E/Z)-2,2-dimethylpropylidene]amino}-4-(methylthio)-1-phenylbutan-1-one

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Technology Process of 2-benzyl-2-{[(1E/Z)-2,2-dimethylpropylidene]amino}-4-(methylthio)-1-phenylbutan-1-one

There total 4 articles about 2-benzyl-2-{[(1E/Z)-2,2-dimethylpropylidene]amino}-4-(methylthio)-1-phenylbutan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 620-05-3
iodomethylbenzene

: 649723-54-6
(2R,4R)-3-benzoyl-2-tert-butyl-4-[2-(methylthio)ethyl]-1,3-oxazolidin-5-one

: 2-amino-2-benzyl-4-(methylthio)-1-phenylbutan-1-one

: 649723-56-8
2-benzyl-2-{[(1E/Z)-2,2-dimethylpropylidene]amino}-4-(methylthio)-1-phenylbutan-1-one

: 649723-55-7
(2R,4R)-3-benzoyl-4-benzyl-2-tert-butyl-4-[2-(methylthio)ethyl]-1,3-oxazolidin-5-one

Guidance literature:: (2R,4R)-3-benzoyl-2-tert-butyl-4-[2-(methylthio)ethyl]-1,3-oxazolidin-5-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -60 ℃; for 0.5h;

iodomethylbenzene; In tetrahydrofuran; at 20 ℃; for 5h; Further stages.;
DOI:10.1039/b303471m

Reference yield: 9.0%

: 100-39-0
benzyl bromide

: 649723-54-6
(2R,4R)-3-benzoyl-2-tert-butyl-4-[2-(methylthio)ethyl]-1,3-oxazolidin-5-one

: 649723-56-8
2-benzyl-2-{[(1E/Z)-2,2-dimethylpropylidene]amino}-4-(methylthio)-1-phenylbutan-1-one

: 649723-55-7
(2R,4R)-3-benzoyl-4-benzyl-2-tert-butyl-4-[2-(methylthio)ethyl]-1,3-oxazolidin-5-one

Guidance literature:: (2R,4R)-3-benzoyl-2-tert-butyl-4-[2-(methylthio)ethyl]-1,3-oxazolidin-5-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -70 ℃; for 0.666667h;

benzyl bromide; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1039/b303471m

Reference yield:

: 348-67-4,26062-47-5,58576-49-1
D-methionine

: 649723-56-8
2-benzyl-2-{[(1E/Z)-2,2-dimethylpropylidene]amino}-4-(methylthio)-1-phenylbutan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 30 percent / NaOH / CH₂Cl₂

2.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.67 h / -70 °C

2.2: tetrahydrofuran / 5 h / 20 °C

With sodium hydroxide; sodium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b303471m