5-[1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-[1,3,4]oxadiazol-2-ylamine

Base Information

• Chemical Name: 5-[1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-[1,3,4]oxadiazol-2-ylamine
• CAS No.: 885225-86-5
• Molecular Formula: C₁₈H₁₃Cl₂FN₄O
• Molecular Weight: 391.232

Synonyms:5-[1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-[1,3,4]oxadiazol-2-ylamine

Chemical Property of 5-[1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-[1,3,4]oxadiazol-2-ylamine

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Technology Process of 5-[1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-[1,3,4]oxadiazol-2-ylamine

There total 2 articles about 5-[1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-[1,3,4]oxadiazol-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indole-7-carboxylic acid hydrazide (885225-85-4) + bromocyane (506-68-3) → 5-[1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-[1,3,4]oxadiazol-2-ylamine (885225-86-5)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2009.11.073

Reference yield: 73.0%

bromocyane (506-68-3) → 5-[1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-[1,3,4]oxadiazol-2-ylamine (885225-86-5)

Guidance literature:

1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indole-7-carboxylic acid hydrazide; With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 0.0833333h;

bromocyane; In 1,4-dioxane; water; at 20 ℃; for 2h;

Reference yield: 90.0%

trifluoracetyl chloride (354-32-5) + 5-[1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-[1,3,4]oxadiazol-2-ylamine (885225-86-5) → N-{5-[1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-[1,3,4]oxadiazol-2-yl}-2,2,2-trifluoro-acetamide

Guidance literature:

With pyridine; dmap; at 20 - 70 ℃;

DOI:10.1016/j.tetlet.2009.11.073

upstream raw materials:

bromocyane

1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indole-7-carboxylic acid hydrazide

Downstream raw materials:

C₃₀H₂₂Cl₂FN₄O₂P

{5-[1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-[1,3,4]oxadiazol-2-yl}-phosphoramidic acid bis-(2,4-dichloro-phenyl) ester

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