Technology Process of ethyl (S)-3-benzyloxy-2,2-dimethylbutanoate
There total 2 articles about ethyl (S)-3-benzyloxy-2,2-dimethylbutanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetra-(n-butyl)ammonium iodide; sodium hydride;
In
tetrahydrofuran;
at 20 ℃;
for 5h;
DOI:10.1246/bcsj.73.485
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diphenylsilane / [Rh(cod)2]BF4; (S,S)-2,2''-bis[(R)-1-(Et2P)ethyl]-1,1''-biferrocene / tetrahydrofuran / 24 h / -30 °C
1.2: 80 percent / aq. HCl / tetrahydrofuran; methanol / 1 h / 0 °C
2.1: 33 percent / sodium hydride; tetrabutylammonium iodide / tetrahydrofuran / 5 h / 20 °C
With
diphenylsilane; tetra-(n-butyl)ammonium iodide; sodium hydride;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (S,S)-2,2''-bis[(R)-1-(Et2P)ethyl]-1,1''-biferrocene;
In
tetrahydrofuran;
1.1: hydrosilylation / 1.2: Hydrolysis / 2.1: Etherification;
DOI:10.1246/bcsj.73.485
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium tetrahydridoaluminate / diethyl ether / 1.5 h / 0 °C
2: dimethyl sulfoxide; oxalyl chloride; triethylamine / CH2Cl2 / 0.5 h / -60 - 20 °C
With
lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
diethyl ether; dichloromethane;
1: Reduction / 2: Swern oxidation;
DOI:10.1246/bcsj.73.485