methyl (2S)-{[(benzyloxy)carbonyl]amino}(4,4-difluorocyclohexyl)ethanoate

Base Information

Chemical Name:methyl (2S)-{[(benzyloxy)carbonyl]amino}(4,4-difluorocyclohexyl)ethanoate
CAS No.:1241377-40-1
Molecular Formula:C₁₇H₂₁F₂NO₄
Molecular Weight:341.355
Hs Code.:

Synonyms:methyl (2S)-{[(benzyloxy)carbonyl]amino}(4,4-difluorocyclohexyl)ethanoate

Suppliers and Price of methyl (2S)-{[(benzyloxy)carbonyl]amino}(4,4-difluorocyclohexyl)ethanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of methyl (2S)-{[(benzyloxy)carbonyl]amino}(4,4-difluorocyclohexyl)ethanoate

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of methyl (2S)-{[(benzyloxy)carbonyl]amino}(4,4-difluorocyclohexyl)ethanoate

There total 6 articles about methyl (2S)-{[(benzyloxy)carbonyl]amino}(4,4-difluorocyclohexyl)ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1241377-38-7
methyl (2S)-{[(benzyloxy)carbonyl]amino}(4-oxocyclohexyl)ethanoate

: 1241377-40-1
methyl (2S)-{[(benzyloxy)carbonyl]amino}(4,4-difluorocyclohexyl)ethanoate

Guidance literature:: methyl (2S)-{[(benzyloxy)carbonyl]amino}(4-oxocyclohexyl)ethanoate; With diethylamino-sulfur trifluoride; In dichloromethane; at 20 ℃; for 1h;

With ruthenium trichloride; sodium periodate; In acetonitrile; at 20 ℃; for 5h;
DOI:10.1021/jm301674z

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1241377-40-1
methyl (2S)-{[(benzyloxy)carbonyl]amino}(4,4-difluorocyclohexyl)ethanoate

Guidance literature:: Multi-step reaction with 4 steps

1: N,N,N',N'-tetramethylguanidine / ethyl acetate / 72 h / 20 °C

2: hydrogen / (-)-bis((2S,5S)-2,5-dimethylphospholano)ethane(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 72 h / 20 °C / 3620.13 Torr

3: water; dichloro-acetic acid / acetic acid / 72 h / 20 °C

4: (bis-(2-methoxyethyl)amino)sulfur trufluoride / ethanol / dichloromethane / 20 °C

With dichloro-acetic acid; water; hydrogen; (bis-(2-methoxyethyl)amino)sulfur trufluoride; N,N,N',N'-tetramethylguanidine; ethanol; (-)-bis((2S,5S)-2,5-dimethylphospholano)ethane(cyclooctadiene)rhodium(I) tetrafluoroborate; In methanol; dichloromethane; acetic acid; ethyl acetate;

Reference yield:

: 684283-02-1
methyl 2-(benzyloxycarbonylamino)-2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate

: 1241377-40-1
methyl (2S)-{[(benzyloxy)carbonyl]amino}(4,4-difluorocyclohexyl)ethanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / (-)-bis((2S,5S)-2,5-dimethylphospholano)ethane(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 72 h / 20 °C / 3620.13 Torr

2: water; dichloro-acetic acid / acetic acid / 72 h / 20 °C

3: (bis-(2-methoxyethyl)amino)sulfur trufluoride / ethanol / dichloromethane / 20 °C

With dichloro-acetic acid; water; hydrogen; (bis-(2-methoxyethyl)amino)sulfur trufluoride; ethanol; (-)-bis((2S,5S)-2,5-dimethylphospholano)ethane(cyclooctadiene)rhodium(I) tetrafluoroborate; In methanol; dichloromethane; acetic acid;