Technology Process of ((2S,5R,6R,9E)-1-(benzyloxy)-10-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,6-dimethyldec-9-en-5-yloxy)(tert-butyl)dimethylsilane
There total 12 articles about ((2S,5R,6R,9E)-1-(benzyloxy)-10-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,6-dimethyldec-9-en-5-yloxy)(tert-butyl)dimethylsilane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hexamethylsilazane;
In
1,2-dimethoxyethane;
at -60 ℃;
for 2h;
stereoselective reaction;
DOI:10.1016/j.tetlet.2008.11.088
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C
2.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C
2.2: 0.5 h / 0 °C
2.3: 1 h / 0 °C
3.1: 2,6-dimethylpyridine / 0.5 h / 0 °C
4.1: sodium tetrahydroborate; lithium chloride / tetrahydrofuran; ethanol / 6 h / 20 °C
5.1: dipyridinium dichromate / dichloromethane / 20 °C
6.1: ethyl (triphenylphosphoranylidene)acetate / benzene / 24 h / 20 °C
7.1: nickel(II) chloride hexahydrate; sodium hydride / methanol / 0.5 h / 0 °C
8.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
9.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 0 °C
10.1: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / ethanol / 0 °C
11.1: potassium hexamethylsilazane / 1,2-dimethoxyethane; toluene / 0.5 h / -60 °C
11.2: 2 h / -60 °C
With
2,6-dimethylpyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; dipyridinium dichromate; nickel(II) chloride hexahydrate; hexaammonium heptamolybdate tetrahydrate; di-isopropyl azodicarboxylate; di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; potassium hexamethylsilazane; sodium hydride; Dess-Martin periodane; triphenylphosphine; ethyl (triphenylphosphoranylidene)acetate; lithium chloride;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; toluene; benzene;
2.1: |Evans Aldol Reaction / 2.2: |Evans Aldol Reaction / 11.1: |Julia-Kocienski Olefination / 11.2: |Julia-Kocienski Olefination;
DOI:10.1016/j.tetasy.2012.07.006
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / ethanol / 0 °C
2.1: potassium hexamethylsilazane / 1,2-dimethoxyethane; toluene / 0.5 h / -60 °C
2.2: 2 h / -60 °C
With
hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide; potassium hexamethylsilazane;
In
1,2-dimethoxyethane; ethanol; toluene;
2.1: |Julia-Kocienski Olefination / 2.2: |Julia-Kocienski Olefination;
DOI:10.1016/j.tetasy.2012.07.006
