1H-Pyrrolizine-7a(5H)-carboxylicacid,tetrahydro-,methylester(9CI)

Base Information

• Chemical Name: 1H-Pyrrolizine-7a(5H)-carboxylicacid,tetrahydro-,methylester(9CI)
• CAS No.: 117375-15-2
• Molecular Formula: C₉H₁₅NO₂
• Molecular Weight: 169.224
• Hs Code.: 2933990090
• Mol file: 117375-15-2.mol

Synonyms:Methylhexahydro-1H-pyrrolizine-7a-carboxylate; NSC 697383

Chemical Property of 1H-Pyrrolizine-7a(5H)-carboxylicacid,tetrahydro-,methylester(9CI)

Chemical Property:

• Boiling Point: 213.6±23.0 °C(Predicted)
• PKA: 8.82±0.40(Predicted)
• PSA: 29.54000
• Density: 1.12±0.1 g/cm3(Predicted)
• LogP: 0.72570
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyltetrahydro-1H-pyrrolizine-7a(5H)-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolizine-7a(5H)-carboxylicacid,tetrahydro-,methylester(9CI)

There total 10 articles about 1H-Pyrrolizine-7a(5H)-carboxylicacid,tetrahydro-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ methyl 2,3,5,6,7,7a-hexahydropyrrolizine-7a-carboxylate (117375-15-2)

Guidance literature:

Reference yield: 41.0%

9,9-dimethoxy-5-phenylthio-1-azabicyclo<3.3.1>nonane (117375-13-0) → methyl 2,3,5,6,7,7a-hexahydropyrrolizine-7a-carboxylate (117375-15-2)

Guidance literature:

With hydrogenchloride; In methanol; for 2.5h; Heating;

Reference yield: 39.8%

methyl (2S)-2-(3-bromopropyl)-N-(tert-butoxycarbonyl)pyrrolidine-2-carboxylate (474010-94-1) → methyl 2,3,5,6,7,7a-hexahydropyrrolizine-7a-carboxylate (117375-15-2)

Guidance literature:

With hydrogenchloride; In ethyl acetate;

upstream raw materials:

9,9-dimethoxy-5-phenylthio-1-azabicyclo<3.3.1>nonane

9,9-dichloro-5-phenylthio-1-azabicyclo<3.3.1>nonane

7a-trichloromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine

5,9,9-trichloro-1-azabicyclo<3.3.1>nonane

Downstream raw materials:

5-azabicyclo[3.3.0]octanecarboxaldehyde