Phosphoric acid allyl ester (S)-1-benzyloxymethyl-allyl ester phenyl ester

Base Information

• Chemical Name: Phosphoric acid allyl ester (S)-1-benzyloxymethyl-allyl ester phenyl ester
• CAS No.: 917596-06-6
• Molecular Formula: C₂₀H₂₃O₅P
• Molecular Weight: 374.373
• Mol file: 917596-06-6.mol

Synonyms:Phosphoric acid allyl ester (S)-1-benzyloxymethyl-allyl ester phenyl ester

Chemical Property of Phosphoric acid allyl ester (S)-1-benzyloxymethyl-allyl ester phenyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Phosphoric acid allyl ester (S)-1-benzyloxymethyl-allyl ester phenyl ester

There total 2 articles about Phosphoric acid allyl ester (S)-1-benzyloxymethyl-allyl ester phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

allyl diphenyl phosphate (19206-69-0) + (S)-1-(benzyloxy)but-3-en-2-ol (109613-59-4) → Phosphoric acid allyl ester (S)-1-benzyloxymethyl-allyl ester phenyl ester (917596-06-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -40 - 20 ℃; for 8h;

DOI:10.1021/ol061756r

Reference yield:

(S)-benzyl glycidyl ether (2930-05-4,14618-80-5,89616-40-0,16495-13-9) → Phosphoric acid allyl ester (S)-1-benzyloxymethyl-allyl ester phenyl ester (917596-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / BuLi / tetrahydrofuran / -30 - 20 °C

2: 71 percent / BuLi / tetrahydrofuran / 8 h / -40 - 20 °C

With n-butyllithium; In tetrahydrofuran;

DOI:10.1021/ol061756r

Reference yield: 76.0%

Phosphoric acid allyl ester (S)-1-benzyloxymethyl-allyl ester phenyl ester (917596-06-6) → (S)-4-Benzyloxymethyl-2-phenoxy-4,7-dihydro-[1,3,2]dioxaphosphepine 2-oxide (915315-07-0)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 1.5h; Heating;

DOI:10.1021/ol061756r

upstream raw materials:

allyl diphenyl phosphate

(S)-1-(benzyloxy)but-3-en-2-ol

(S)-benzyl glycidyl ether

Downstream raw materials:

(S)-4-Benzyloxymethyl-2-phenoxy-4,7-dihydro-[1,3,2]dioxaphosphepine 2-oxide