di-tert-butyl [(2S)-4-benzyloxy-2-(3,5-dinitrobenzoyloxy)]butylmalonate

Base Information

Chemical Name:di-tert-butyl [(2S)-4-benzyloxy-2-(3,5-dinitrobenzoyloxy)]butylmalonate
CAS No.:865375-30-0
Molecular Formula:C₂₉H₃₆N₂O₁₁
Molecular Weight:588.612
Hs Code.:

Synonyms:di-tert-butyl [(2S)-4-benzyloxy-2-(3,5-dinitrobenzoyloxy)]butylmalonate

Suppliers and Price of di-tert-butyl [(2S)-4-benzyloxy-2-(3,5-dinitrobenzoyloxy)]butylmalonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of di-tert-butyl [(2S)-4-benzyloxy-2-(3,5-dinitrobenzoyloxy)]butylmalonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of di-tert-butyl [(2S)-4-benzyloxy-2-(3,5-dinitrobenzoyloxy)]butylmalonate

There total 1 articles about di-tert-butyl [(2S)-4-benzyloxy-2-(3,5-dinitrobenzoyloxy)]butylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 99-34-3
3,5-dinitrobenzoic acid

: 161111-09-7
Di-tert-butyl (4-(benzyloxy)-(S)-2-hydroxybutyl)malonate

: 865375-30-0
di-tert-butyl [(2S)-4-benzyloxy-2-(3,5-dinitrobenzoyloxy)]butylmalonate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1055/s-2005-870007

Reference yield: 81.0%

: 865375-30-0
di-tert-butyl [(2S)-4-benzyloxy-2-(3,5-dinitrobenzoyloxy)]butylmalonate

: di-tert-butyl (2R)-2-[2-benzyloxyethyl]cyclopropane-1,1-dicarboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; tert-butyl alcohol; at 20 ℃; for 48h;
DOI:10.1055/s-2005-870007

Reference yield:

: 865375-30-0
di-tert-butyl [(2S)-4-benzyloxy-2-(3,5-dinitrobenzoyloxy)]butylmalonate

: methyl (4E)-2-{[(benzyloxy)carbonyl]amino}-6-oxohex-4-enoate

Guidance literature:: Multi-step reaction with 11 steps

1: sodium hydride / tetrahydrofuran; tert-butyl alcohol / 48 h / 20 °C

2: hydrogen / palladium on activated charcoal / methanol / 1.5 h / atmospheric pressure

3: trifluoroacetic acid / dichloromethane / Heating

4: TEA / acetone; benzene / 0.5 h / 0 °C

5: sodium azide / acetone / 0.5 h

6: toluene / 2 h / Heating

7: toluene / Heating

8: lithium hydroxide / tetrahydrofuran / 20 °C

9: potassium carbonate / N,N-dimethyl-formamide; acetonitrile

10: sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 0.25 h / cooling

11: 20 °C

With lithium hydroxide; sodium azide; TEA; hydrogen; sulfur trioxide pyridine complex; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; tert-butyl alcohol; benzene; 6: Curtius reaction;
DOI:10.1055/s-2005-870007