methyl (1R,2R)-1-{[(benzyloxy)carbonyl]amino}-2-(2-hydroxyethyl)cyclopropanecarboxylate

Base Information

Chemical Name:methyl (1R,2R)-1-{[(benzyloxy)carbonyl]amino}-2-(2-hydroxyethyl)cyclopropanecarboxylate
CAS No.:865375-29-7
Molecular Formula:C₁₅H₁₉NO₅
Molecular Weight:293.32
Hs Code.:

Synonyms:

Suppliers and Price of methyl (1R,2R)-1-{[(benzyloxy)carbonyl]amino}-2-(2-hydroxyethyl)cyclopropanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (1R,2R)-1-{[(benzyloxy)carbonyl]amino}-2-(2-hydroxyethyl)cyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (1R,2R)-1-{[(benzyloxy)carbonyl]amino}-2-(2-hydroxyethyl)cyclopropanecarboxylate

There total 10 articles about methyl (1R,2R)-1-{[(benzyloxy)carbonyl]amino}-2-(2-hydroxyethyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: di-tert-butyl (2R)-2-[2-benzyloxyethyl]cyclopropane-1,1-dicarboxylate

: 865375-29-7
methyl (1R,2R)-1-{[(benzyloxy)carbonyl]amino}-2-(2-hydroxyethyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogen / palladium on activated charcoal / methanol / 1.5 h / atmospheric pressure

2: trifluoroacetic acid / dichloromethane / Heating

3: TEA / acetone; benzene / 0.5 h / 0 °C

4: sodium azide / acetone / 0.5 h

5: toluene / 2 h / Heating

6: toluene / Heating

7: lithium hydroxide / tetrahydrofuran / 20 °C

8: potassium carbonate / N,N-dimethyl-formamide; acetonitrile

With lithium hydroxide; sodium azide; TEA; hydrogen; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; benzene; 5: Curtius reaction;
DOI:10.1055/s-2005-870007

Reference yield:

: 865375-30-0
di-tert-butyl [(2S)-4-benzyloxy-2-(3,5-dinitrobenzoyloxy)]butylmalonate

: 865375-29-7
methyl (1R,2R)-1-{[(benzyloxy)carbonyl]amino}-2-(2-hydroxyethyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: sodium hydride / tetrahydrofuran; tert-butyl alcohol / 48 h / 20 °C

2: hydrogen / palladium on activated charcoal / methanol / 1.5 h / atmospheric pressure

3: trifluoroacetic acid / dichloromethane / Heating

4: TEA / acetone; benzene / 0.5 h / 0 °C

5: sodium azide / acetone / 0.5 h

6: toluene / 2 h / Heating

7: toluene / Heating

8: lithium hydroxide / tetrahydrofuran / 20 °C

9: potassium carbonate / N,N-dimethyl-formamide; acetonitrile

With lithium hydroxide; sodium azide; TEA; hydrogen; sodium hydride; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; tert-butyl alcohol; benzene; 6: Curtius reaction;
DOI:10.1055/s-2005-870007

Reference yield:

: 161111-09-7
Di-tert-butyl (4-(benzyloxy)-(S)-2-hydroxybutyl)malonate

: 865375-29-7
methyl (1R,2R)-1-{[(benzyloxy)carbonyl]amino}-2-(2-hydroxyethyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 10 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran

2: sodium hydride / tetrahydrofuran; tert-butyl alcohol / 48 h / 20 °C

3: hydrogen / palladium on activated charcoal / methanol / 1.5 h / atmospheric pressure

4: trifluoroacetic acid / dichloromethane / Heating

5: TEA / acetone; benzene / 0.5 h / 0 °C

6: sodium azide / acetone / 0.5 h

7: toluene / 2 h / Heating

8: toluene / Heating

9: lithium hydroxide / tetrahydrofuran / 20 °C

10: potassium carbonate / N,N-dimethyl-formamide; acetonitrile

With lithium hydroxide; sodium azide; TEA; hydrogen; sodium hydride; potassium carbonate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; tert-butyl alcohol; benzene; 1: Mitsunobu reaction / 7: Curtius reaction;
DOI:10.1055/s-2005-870007