2-butyl-4,5-dihydro-4-oxo-3-[2'-(tetrazol-5-yl)-biphenyl-4-ylmethyl]-5-(o-ethoxycarbonyl-benzyl)-3H-imidazo[4,5-c]-pyridine

Base Information

Chemical Name:2-butyl-4,5-dihydro-4-oxo-3-[2'-(tetrazol-5-yl)-biphenyl-4-ylmethyl]-5-(o-ethoxycarbonyl-benzyl)-3H-imidazo[4,5-c]-pyridine
CAS No.:156222-03-6
Molecular Formula:C₃₄H₃₃N₇O₃
Molecular Weight:587.681
Hs Code.:

Synonyms:2-butyl-4,5-dihydro-4-oxo-3-[2'-(tetrazol-5-yl)-biphenyl-4-ylmethyl]-5-(o-ethoxycarbonyl-benzyl)-3H-imidazo[4,5-c]-pyridine

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Chemical Property of 2-butyl-4,5-dihydro-4-oxo-3-[2'-(tetrazol-5-yl)-biphenyl-4-ylmethyl]-5-(o-ethoxycarbonyl-benzyl)-3H-imidazo[4,5-c]-pyridine

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Technology Process of 2-butyl-4,5-dihydro-4-oxo-3-[2'-(tetrazol-5-yl)-biphenyl-4-ylmethyl]-5-(o-ethoxycarbonyl-benzyl)-3H-imidazo[4,5-c]-pyridine

There total 9 articles about 2-butyl-4,5-dihydro-4-oxo-3-[2'-(tetrazol-5-yl)-biphenyl-4-ylmethyl]-5-(o-ethoxycarbonyl-benzyl)-3H-imidazo[4,5-c]-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39217-08-8
2-chloropyridine-3,4-diamine

: 156222-03-6
2-butyl-4,5-dihydro-4-oxo-3-[2'-(tetrazol-5-yl)-biphenyl-4-ylmethyl]-5-(o-ethoxycarbonyl-benzyl)-3H-imidazo[4,5-c]-pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / tetrahydrofuran / Ambient temperature

2: 1.) potassium t-butoxide, 2.) 18percent HCl / 1.) NMP, 5 h, 2.) 105 deg C, 40 h

3: 1.) potassium tert-butoxide / 1.) DMF, RT, 2.) DMF, RT

4: 1.) trimethyltin azide, 2.) HCl / 1.) toluene, reflux, 2.) methanol

With hydrogenchloride; trimethyltin azide; potassium tert-butylate; In tetrahydrofuran;
DOI:10.1021/jm00037a014

Reference yield:

: 2082-59-9
pentanoic anhydride

: 156222-03-6
2-butyl-4,5-dihydro-4-oxo-3-[2'-(tetrazol-5-yl)-biphenyl-4-ylmethyl]-5-(o-ethoxycarbonyl-benzyl)-3H-imidazo[4,5-c]-pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / tetrahydrofuran / Ambient temperature

2: 1.) potassium t-butoxide, 2.) 18percent HCl / 1.) NMP, 5 h, 2.) 105 deg C, 40 h

3: 1.) potassium tert-butoxide / 1.) DMF, RT, 2.) DMF, RT

4: 1.) trimethyltin azide, 2.) HCl / 1.) toluene, reflux, 2.) methanol

With hydrogenchloride; trimethyltin azide; potassium tert-butylate; In tetrahydrofuran;
DOI:10.1021/jm00037a014

Reference yield:

: 145047-34-3
2-butyl-4-chloro-3H-imidazo<4,5-c>pyridine

: 156222-03-6
2-butyl-4,5-dihydro-4-oxo-3-[2'-(tetrazol-5-yl)-biphenyl-4-ylmethyl]-5-(o-ethoxycarbonyl-benzyl)-3H-imidazo[4,5-c]-pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 52 percent / 15percent hydrochloric acid / dimethylformamide / 24 h / Heating

2: 41 percent / potassium carbonate / dimethylformamide / Ambient temperature

3: 1.) potassium tert-butoxide / 1.) DMF, RT, 2.) DMF, RT

4: 1.) trimethyltin azide, 2.) HCl / 1.) toluene, reflux, 2.) methanol

With hydrogenchloride; trimethyltin azide; potassium tert-butylate; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00037a014