2082-59-9

Basic information

• Product Name: VALERIC ANHYDRIDE
• Synonyms: VALERIC ANHYDRIDE;Pentanoic acid, anhydride;Pentanoicacid,anhydride;pentanoicacidanhydride;PENTANOIC ANHYDRIDE;N-PENTANOIC ANHYDRIDE;N-VALERIC ANHYDRIDE;VALERIC ANHYDRIDE 98%
• CAS NO: 2082-59-9
• Molecular Formula: C₁₀H₁₈O₃
• Molecular Weight: 186.25
• EINECS: 218-212-9
• Mol File: 2082-59-9.mol
• Article Data: 15

Chemical Properties

• Melting Point: −56 °C(lit.)
• Boiling Point: 228-230 °C(lit.)
• Flash Point: 214 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 0.944 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.0758mmHg at 25°C
• Refractive Index: n20/D 1.421(lit.)
• Storage Temp.: Store below +30°C.
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• BRN: 1770130
• CAS DataBase Reference: VALERIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: VALERIC ANHYDRIDE(2082-59-9)
• EPA Substance Registry System: VALERIC ANHYDRIDE(2082-59-9)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 3
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 2082-59-9(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to yellow liquid

Uses

Different sources of media describe the Uses of 2082-59-9 differently. You can refer to the following data:
1. Valeric Anhydride is used in the synthesis of non-imadazole histamine H3-antagonists. Also used in the preparation of millepachine derivatives as a new class of tubulin polymerization inhibitors.
2. Valeric anhydride can be used as a reactant to synthesize:Alkyl 9-nitrocamptothecin esters by the esterification reaction.Modified bismuth metal-organic frameworks (Bi-MOFs).O-acylated chitosan nanofibers (CSNFs) for potential usage in biomaterials and food packaging.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C10H18O3/c1-3-5-7-9(11)13-10(12)8-6-4-2/h3-8H2,1-2H3

Upstream product

• 108-24-7 acetic anhydride 
• 109-52-4 valeric acid 
• 109-72-8 n-butyllithium 
• 86950-96-1 1-(methoxycarbonyl)pyridine-1-ium chloride 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 7732-18-5 water 
• 7553-56-2 iodine 
• 79-37-8 oxalyl dichloride 
• 56-23-5 tetrachloromethane 
• 1942-46-7 5-decyne 
• 10028-15-6 ozone 
• 64-19-7 acetic acid 
• 71-41-0 pentan-1-ol 
• 115956-35-9 formic-valeric anhydride 

Downstream Products

• 3194-17-0 1-furan-2-yl-pentan-1-one 
• 725266-67-1 6-ethyl-3-valeryl-pyran-2,4-dione 
• 551-08-6 3-butylidenephthalide 
• 5394-88-7 1-(4-methoxy-3-methylphenyl)-1-pentanone 
• 63042-28-4 estradiol divalerate 
• 128788-26-1 3-valeryloxy-estra-1,3,5(10)-trien-17-one 
• 3129-43-9 testosterone-17-valerate 
• 7726-03-6 cholesteryl n-pentanoate 
• 65201-68-5 benzene-hexa-n-pentanoate 
• 6677-15-2 17-valeryloxy-pregn-4-ene-3,20-dione 
• 2706-90-3 Perfluoropentanoic acid 
• 19393-14-7 (Z)-3-(2-nitrophenyl)-2-phenylprop-2-enoic acid 
• 64206-54-8 2-[(1-oxopentyl)oxy]-benzoic acid 
• 5451-78-5 valeric acid-(2-bromo-ethyl ester) 

Relevant articles and documents

ON THE REGIOSELECTIVITY OF THE REACTION OF N-METHOXYCARBONYLPYRIDINIUM CHLORIDE WITH GRIGNARD REAGENTS: HIGHLY REGIOSELECTIVE SYNTHESIS OF 2-SUBSTITUTED N-METHOXYCARBONYL-1,2-DIHYDROPYRIDINES.

Whereas alkyl Grignard reagents undergo 1,2- and 1,4-additions to N-methoxycarbonyl-pyridinium chloride in a variable ratio, alkenyl and alkynyl Grignard reagents do the exclusive 1,2-addition to afford 2-substituted N-methoxycarbonyl-1,2-dihydropyridines in fair to excellent yields.

Valeric anhydride preparation method

The present invention discloses a valeric anhydride preparation method comprising the following steps: (a) adding an organic solvent and valeric acid into a reaction vessel, then adding portionwise dicyclohexyl carbodiimide for reaction at the room temperature for 20 to 40 minutes; and (2) removing solid impurities by filtration, recovering the organic solvent by distillation under reduced pressure, after the the organic solvent is completely recovered, heating for distilling under reduced pressure to obtain an object product valeric anhydride. The method uses the valeric acid and the dicyclohexyl carbodiimide for reaction for preparation of the valeric anhydride, the separation process is simple, the obtained valeric anhydride is high in quality, and the valeric anhydride purity reaches 99.3%.

Synthesis of α-diazoketone by the action of diazoalkanes on butyric anhydride

Butyric anhydride reacts with diazo-n-alkanes In dry ether at 0°C gave 1-diazo-1-n-alkyl pentanones.