4-fluoro-2-{2-fluoro-4-[(3-oxopiperazin-1-yl)carbonyl]phenoxy}-5-ethylphenyl ethyl carbonate

Base Information

Chemical Name:4-fluoro-2-{2-fluoro-4-[(3-oxopiperazin-1-yl)carbonyl]phenoxy}-5-ethylphenyl ethyl carbonate
CAS No.:1293368-05-4
Molecular Formula:C₂₂H₂₂F₂N₂O₆
Molecular Weight:448.423
Hs Code.:

Synonyms:4-fluoro-2-{2-fluoro-4-[(3-oxopiperazin-1-yl)carbonyl]phenoxy}-5-ethylphenyl ethyl carbonate

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Chemical Property of 4-fluoro-2-{2-fluoro-4-[(3-oxopiperazin-1-yl)carbonyl]phenoxy}-5-ethylphenyl ethyl carbonate

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Technology Process of 4-fluoro-2-{2-fluoro-4-[(3-oxopiperazin-1-yl)carbonyl]phenoxy}-5-ethylphenyl ethyl carbonate

There total 5 articles about 4-fluoro-2-{2-fluoro-4-[(3-oxopiperazin-1-yl)carbonyl]phenoxy}-5-ethylphenyl ethyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1293368-02-1
4-[4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl]piperazin-2-one

: 541-41-3
chloroformic acid ethyl ester

: 1293368-05-4
4-fluoro-2-{2-fluoro-4-[(3-oxopiperazin-1-yl)carbonyl]phenoxy}-5-ethylphenyl ethyl carbonate

Guidance literature:: With potassium hydroxide; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 64248-62-0
3,4-Difluorobenzonitrile

: 1293368-05-4
4-fluoro-2-{2-fluoro-4-[(3-oxopiperazin-1-yl)carbonyl]phenoxy}-5-ethylphenyl ethyl carbonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / acetonitrile / 80 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 70 °C / Reflux

2.2: Cooling with ice

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

4.1: potassium hydroxide / acetonitrile / 1 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 1065076-45-0
4-ethyl-5-fluoroguaiacol

: 1293368-05-4
4-fluoro-2-{2-fluoro-4-[(3-oxopiperazin-1-yl)carbonyl]phenoxy}-5-ethylphenyl ethyl carbonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / acetonitrile / 80 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 70 °C / Reflux

2.2: Cooling with ice

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

4.1: potassium hydroxide / acetonitrile / 1 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; In methanol; dichloromethane; acetonitrile;