1-isocyano-2-methylpropanephosphonic acid di(4-methylthiophenyl) ester

Base Information

• Chemical Name: 1-isocyano-2-methylpropanephosphonic acid di(4-methylthiophenyl) ester
• CAS No.: 1275615-39-8
• Molecular Formula: C₁₉H₂₂NO₃PS₂
• Molecular Weight: 407.494
• Mol file: 1275615-39-8.mol

Synonyms:1-isocyano-2-methylpropanephosphonic acid di(4-methylthiophenyl) ester

Chemical Property of 1-isocyano-2-methylpropanephosphonic acid di(4-methylthiophenyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-isocyano-2-methylpropanephosphonic acid di(4-methylthiophenyl) ester

There total 5 articles about 1-isocyano-2-methylpropanephosphonic acid di(4-methylthiophenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-formamido-2-methylpropanephosphonic acid di(4-methylthiophenyl) ester (1312758-94-3) → 1-isocyano-2-methylpropanephosphonic acid di(4-methylthiophenyl) ester (1275615-39-8)

Guidance literature:

With triethylamine; trichlorophosphate; In dichloromethane; at 0 ℃;

DOI:10.1016/j.bmc.2010.12.008

Reference yield:

tris(4-(methylthio)phenyl) phosphite (22945-49-9) → 1-isocyano-2-methylpropanephosphonic acid di(4-methylthiophenyl) ester (1275615-39-8)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / 2 h / 80 °C

2: hydrogen bromide; acetic acid / 2 h / 20 °C

3: triethylamine / dichloromethane / 20 °C

4: triethylamine; trichlorophosphate / dichloromethane / 0 °C

With hydrogen bromide; acetic acid; triethylamine; trichlorophosphate; In dichloromethane;

DOI:10.1016/j.bmc.2010.12.008

Reference yield:

benzyl 1-(bis(4-(methylthio)phenoxy)phosphoryl)-2-methylpropylcarbamate (1282624-42-3) → 1-isocyano-2-methylpropanephosphonic acid di(4-methylthiophenyl) ester (1275615-39-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen bromide; acetic acid / 2 h / 20 °C

2: triethylamine / dichloromethane / 20 °C

3: triethylamine; trichlorophosphate / dichloromethane / 0 °C

With hydrogen bromide; acetic acid; triethylamine; trichlorophosphate; In dichloromethane;

DOI:10.1016/j.bmc.2010.12.008

upstream raw materials:

tris(4-(methylthio)phenyl) phosphite

benzyl 1-(bis(4-(methylthio)phenoxy)phosphoryl)-2-methylpropylcarbamate

1-formamido-2-methylpropanephosphonic acid di(4-methylthiophenyl) ester

4-hydroxythioanisole