2-iodo-3,4,5-trimethoxy-N-((S)-2-(2-methoxymethylpyrrolidin-1-yl))benzamide

Base Information

Chemical Name:2-iodo-3,4,5-trimethoxy-N-((S)-2-(2-methoxymethylpyrrolidin-1-yl))benzamide
CAS No.:1131192-60-3
Molecular Formula:C₁₆H₂₃IN₂O₅
Molecular Weight:450.274
Hs Code.:

Synonyms:2-iodo-3,4,5-trimethoxy-N-((S)-2-(2-methoxymethylpyrrolidin-1-yl))benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-iodo-3,4,5-trimethoxy-N-((S)-2-(2-methoxymethylpyrrolidin-1-yl))benzamide

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Technology Process of 2-iodo-3,4,5-trimethoxy-N-((S)-2-(2-methoxymethylpyrrolidin-1-yl))benzamide

There total 1 articles about 2-iodo-3,4,5-trimethoxy-N-((S)-2-(2-methoxymethylpyrrolidin-1-yl))benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 59983-39-0,187035-29-6
(S)-1-amino-2-(methoxymethyl)pyrrolidine

: 139058-94-9
2-iodo-3,4,5-trimethoxybenzoyl chloride

: 1131192-60-3
2-iodo-3,4,5-trimethoxy-N-((S)-2-(2-methoxymethylpyrrolidin-1-yl))benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tetasy.2008.11.021

Reference yield: 83.0%

: 93-58-3,5705-52-2,80226-58-0
benzoic acid methyl ester

: 1131192-60-3
2-iodo-3,4,5-trimethoxy-N-((S)-2-(2-methoxymethylpyrrolidin-1-yl))benzamide

: 1131192-53-4
3-hydroxy-4,5,6-trimethoxy-2-((S)-2-methoxymethylpyrrolidin-1-yl)-3-phenyl-2,3-dihydro-1H-isoindol-1-one

Guidance literature:: 2-iodo-3,4,5-trimethoxy-N-((S)-2-(2-methoxymethylpyrrolidin-1-yl))benzamide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 3h;

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -30 ℃;

benzoic acid methyl ester; Further stages;
DOI:10.1016/j.tetasy.2008.11.021

Reference yield: 78.0%

: 1131192-60-3
2-iodo-3,4,5-trimethoxy-N-((S)-2-(2-methoxymethylpyrrolidin-1-yl))benzamide

: 98-88-4
benzoyl chloride

: 1131192-43-2
N-(2-iodo-3,4,5-trimethoxybenzoyl)-N-((S)-2-methoxymethylpyrrolidin-1-yl)benzamide

Guidance literature:: 2-iodo-3,4,5-trimethoxy-N-((S)-2-(2-methoxymethylpyrrolidin-1-yl))benzamide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 3h;

benzoyl chloride; In tetrahydrofuran; for 6h; Reflux;
DOI:10.1016/j.tetasy.2008.11.021